Epidemiology of SARS-CoV-2 antibodies among firefighters/paramedics of a US fire department: a cross-sectional study
Epidemiology of SARS-CoV-2 antibodies among firefighters/paramedics of a US fire department: a cross-sectional study
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DOI：
10.1136/oemed-2020-106676
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发表时间：
2020-12-01
影响因子：
4.9
通讯作者：
Kobetz, Erin
中科院分区：
文献类型：
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作者：
Caban-Martinez, Alberto J.;Schaefer-Solle, Natasha;Kobetz, Erin
目的我们估计SARS-CoV-2抗体的点血清阳性率在前线消防员/护理人员的佛罗里达消防部门位于震中的国家爆发。方法横断面研究设计，估计点血清阳性率的SARS-CoV-2抗体使用快速免疫球蛋白（IG）M-IgG结合点的护理侧流免疫测定法在前线消防员/护理人员中收集超过2- 10年。日期间，2020年4月16日至17日。消防部门人员在指定消防站预定的免下车抗体测试前一天通过电子邮件发送了一个调查链接，评估COVID-19症状和工作暴露。休班和值班消防员/护理人员驾驶他们的个人车辆或值班发动机/救援卡车通过消防站/培训设施进行SARS-CoV-2抗体检测。结果在组成消防部门劳动力的203名消防员/护理人员中，SARS-CoV-2抗体阳性率为8.9%，其中IgG阳性8例（3.9%），IgM阳性8例（3.9%），IgG/IgM阳性2例（0.1%）。血清学试验的阳性预测值（PPV）估计为33.2%，阴性预测值为99.3%。与血清学阴性者相比，消防员/护理人员接触COVID-19病例的平均数量（即，在感染者（实验室确诊或可能的COVID-19患者）的6英尺范围内>= 15分钟）在血清学阳性者中更高（13.3例vs 7.31例; p=0.022）。与SARS-CoV-2抗体检测阴性的消防员/护理人员相比，抗体阳性的消防员/护理人员均未报告接受过年度流感疫苗接种（0.0%对21.0%;结论SARS-CoV-2 IgM-IgG抗体快速检测证实了早期和晚期SARS-CoV-2 IgM-IgG抗体阳性。阶段感染的消防员劳动力提供洞察力，以更广泛的医疗监督项目返回工作的消防员/护理人员。鉴于本研究于2020年4月使用的血清学检测的PPV相对较低，应谨慎解释检测结果。
ObjectivesWe estimate the point seroprevalence of SARS-CoV-2 antibodies in the frontline firefighter/paramedic workforce of a South Florida fire department located in the epicentre of a State outbreak.MethodsA cross-sectional study design was used to estimate the point seroprevalence of SARS-CoV-2 antibodies using a rapid immunoglobulin (Ig)M-IgG combined point-of-care lateral flow immunoassay among frontline firefighters/paramedics collected over a 2-day period, 16-17 April 2020. Fire department personnel were emailed a survey link assessing COVID-19 symptoms and work exposures the day prior to the scheduled drive-through antibody testing at a designated fire station. Off-duty and on-duty firefighter/paramedic personnel drove through the fire station/training facility in their personal vehicles or on-duty engine/rescue trucks for SARS-CoV-2 antibody testing.ResultsAmong the 203 firefighters/paramedics that make up the fire department workforce, 18 firefighters/paramedics (8.9%) tested positive for SARS-CoV-2 antibodies, of which 8 firefighters/paramedics (3.9%) were IgG positive only, 8 (3.9%) were IgM positive only and 2 (0.1%) were IgG/IgM positive. The positive predictive value (PPV) of the serological test is estimated to be 33.2% and the negative predictive value is 99.3%. The average number of COVID-19 case contacts (ie, within 6 feet of an infected person (laboratory-confirmed or probable COVID-19 patient) for >= 15 min) experienced by firefighters/paramedics was higher for those with positive serology compared with those with negative (13.3 cases vs 7.31 cases; p=0.022). None of the antibody positive firefighters/paramedics reported receipt of the annual influenza vaccine compared with firefighters/paramedics who tested negative for SARS-CoV-2 antibodies (0.0% vs 21.0%; p=0.027).ConclusionRapid SARS-CoV-2 IgM-IgG antibody testing documented early-stage and late-stage infection in a firefighter workforce providing insight to a broader medical surveillance project on return to work for firefighters/paramedics. Given the relatively low PPV of the serological test used in this study back in April 2020, caution should be used in interpreting test results.