Connectional and architectonic evidence for dorsal and ventral V3, and dorsomedial area in marmoset monkeys
Connectional and architectonic evidence for dorsal and ventral V3, and dorsomedial area in marmoset monkeys
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DOI：
10.1523/jneurosci.21-01-00249.2001
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发表时间：
2001-01-01
影响因子：
5.3
通讯作者：
Kaas, JH
中科院分区：
文献类型：
--
作者：
Lyon, DC;Kaas, JH
第三个视觉区V3的存在，沿着V2的外缘，最初是根据V1的投射提出的。V3的证据从未完全令人信服，因为研究人员未能证明V1投射到腹侧V3，而投射到背侧V3可能归因于背内侧视觉区（DM）。我们已经重新研究了这个问题，将大量的注射到背侧和腹侧部分的V1和随后处理扁平的皮层髓鞘和细胞色素氧化酶，使边界的V1和V2可以准确地确定。这些注射是在小脑的绒猴中进行的，那里的腹侧V1最容易接近，皮层也很容易被压平。结果表明，背侧V1（代表下视觉象限）投射到位于DM和背侧V2之间的狭窄的“背侧V3”，而腹侧V1（代表上视觉象限）投射到狭窄的“腹侧V3”。“这些背侧和腹侧条带的建筑边界非常明显。此外，V1的所有部分项目DM，而腹侧V1连接表明，背外侧区（DL）延伸到腹侧比以前已经建立。我们还在背侧V2、背侧和腹侧DM以及背侧、中央和腹侧中颞（MT）区域内进行注射。这些注射的结果与提出的V3、DM和DL的视网膜组织一致。我们提供了令人信服的证据证明绒猴中存在V3、DM和DL区域，并表明这些区域可能存在于所有灵长类动物中。
The existence of a third visual area, V3, along the outer margin of V2 was originally proposed for primates on the basis of projections from V1. The evidence for V3 was never totally convincing because investigators failed to demonstrate V1 projections to ventral V3, and projections to dorsal V3 could be attributed to the dorsomedial visual area (DM). We have reexamined the issue by placing large injections into both dorsal and ventral portions of V1 and subsequently processing flattened cortex for myelin and cytochrome oxidase so that borders of V1 and V2 could be determined accurately. The injections were in small-brained marmosets, where ventral V1 was most accessible and cortex could be flattened easily. The results indicate that dorsal V1 (representing the lower visual quadrant) projects to a narrow "dorsal V3" located between DM and dorsal V2, whereas ventral V1 (representing the upper visual quadrant) projects to a narrow "ventral V3." Architectonic borders for these dorsal and ventral strips were clearly apparent. In addition, all parts of V1 project to DM, whereas ventral V1 connections indicate that the dorsolateral area (DL) extends more ventral than has been established previously. We also placed injections within dorsal V2, dorsal and ventral DM, and dorsal, central, and ventral middle temporal (MT) area. Results from these injections were consistent with the proposed retinotopic organizations of V3, DM, and DL. We provide compelling evidence for the existence of areas V3, DM, and DL in marmosets and suggest that these areas are likely to be found in all primates.