Red Cell Distribution Width as a Predictor of Prostate Cancer Progression
Red Cell Distribution Width as a Predictor of Prostate Cancer Progression
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DOI：
10.7314/apjcp.2014.15.18.7781
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Gurdal, Mesut
中科院分区：
文献类型：
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作者：
Albayrak, Sebahattin;Zengin, Kursad;Gurdal, Mesut
背景：本研究的目的是探讨红细胞分布宽度(RDW)在前列腺癌中作为一种简单易用的标志物的作用，以及评价RDW作为前列腺癌患者进展的预测指标。材料和方法：在博佐克大学医院泌尿外科门诊接受经直肠超声引导下经直肠活检的前列腺癌患者62例和健康对照组62例，年龄45~75岁，平均年龄。使用我们的实验室信息系统数据库进行数据收集，以检索有关RDW、血红蛋白、前列腺特异性抗原(PSA)和年龄的结果。比较健康对照组和前列腺癌患者的RDW值。进展的高风险定义为Gleason评分(GS)和GT；6，癌症阳性的核心总数为33%，每个核心包含50%的癌细胞，以及前列腺特异性抗原(PSA)水平>；10 ng/ml。根据进展风险对患者进行分类，并根据RDW四分位数将患者分为亚组。结果：前列腺癌患者的平均RDW值为14.6，健康对照组为13.7(P=0.001)。RDW越高，进展风险越高，而RDW值越低，进展风险越低。结论：RDW是一种容易得出的指标，与其他标志物相结合，可能有助于预测前列腺癌的风险和进展。我们建议RDW可以与其他参数一起用于前列腺癌的评估。
Background: The aims of this study were to investigate the utility of red blood cell distribution width (RDW) as a simple and readily available marker in prostate cancer, as well as to evaluate RDW as a predictor of progression in prostate cancer patients. Materials and Methods: We evaluated 62 newly diagnosed prostate cancer patients who underwent transrectal ultrasound (TRUS)-guided biopsy and 62 healthy controls of mean age 64 (range, 45-75) years at the Urology Clinic of Bozok University Hospital. Data collection was performed using our laboratory information system database to retrieve findings regarding RDW, hemoglobin, prostate-specific antigen (PSA), and age. The RDW values were compared between the healthy control group and prostate cancer patients. A high risk of progression as defined as a Gleason score (GS) >6, total number of cores positive for cancer >33%, each core containing >50% cancer cells, and a prostate-specific antigen (PSA) level >10 ng/mL. Patients were classified according to risk of progression, as well as divided into subgroups according to the RDW quartile. Results: The mean RDW value of prostate cancer patients was 14.6, compared with 13.7 in the healthy control group (p=0.001). A higher RDW was associated with an increased risk of progression, whereas a lower RDW value was correlated with a low risk of progression. Conclusions: RDW is an easily derived measure that might, in combination with other markers, help predict prostate cancer risk and progression. We suggest that RDW may be used in combination with other parameters in the assessment of prostate cancer.