Automatic scanning of large tissue areas in neurosurgery using optical coherence tomography
Automatic scanning of large tissue areas in neurosurgery using optical coherence tomography
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DOI：
10.1002/rcs.1425
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发表时间：
2012-09-01
影响因子：
2.5
通讯作者：
Schweikard, A.
中科院分区：
文献类型：
--
作者：
Finke, M.;Kantelhardt, S.;Schweikard, A.
背景光学相干断层扫描（OCT）具有高的空间和时间分辨率，是术中成像的理想模式。一种可能的应用是在神经外科中检测肿瘤侵入的组织，例如在胶质母细胞瘤的完全切除期间。理想情况下，扫描整个切除腔。然而，OCT限于小视场（FOV）和垂直于组织表面的扫描。方法提出一种在脑肿瘤切除术中使用OCT对切除腔进行扫描的新方法。主要的挑战是创建腔的地图，垂直于表面扫描，并合并三维（3D）数据，用于术中可视化和检测残留肿瘤细胞。结果我们的研究结果表明，所提出的方法能够创建高分辨率的切除腔的地图。这些图与显微镜图像的叠加为外科医生提供了关于表面下残留肿瘤组织位置的重要信息。结论我们证明了自动获取完整切除腔的OCT图像是可能的。将来自OCT的深度信息与显微镜图像重叠可以改善对残留肿瘤细胞的检测。版权所有（C）2012约翰威利父子有限公司
Background With its high spatial and temporal resolution, optical coherence tomography (OCT) is an ideal modality for intra-operative imaging. One possible application is to detect tumour invaded tissue in neurosurgery, e.g. during complete resection of glioblastoma. Ideally, the whole resection cavity is scanned. However, OCT is limited to a small field of view (FOV) and scanning perpendicular to the tissue surface. Methods We present a new method to use OCT for scanning of the resection cavity during neurosurgical resection of brain tumours. The main challenges are creating a map of the cavity, scanning perpendicular to the surface and merging the three-dimensional (3D) data for intra-operative visualization and detection of residual tumour cells. Results Our results indicate that the proposed method enables creating high-resolution maps of the resection cavity. An overlay of these maps with the microscope images provides the surgeon with important information on the location of residual tumour tissue underneath the surface. Conclusion We demonstrated that it is possible to automatically acquire an OCT image of the complete resection cavity. Overlaying microscopy images with depth information from OCT could lead to improved detection of residual tumour cells. Copyright (C) 2012 John Wiley & Sons, Ltd.