NONTOLERANCE AND AUTOANTIBODIES TO A TRANSGENIC SELF ANTIGEN EXPRESSED IN PANCREATIC BETA-CELLS
NONTOLERANCE AND AUTOANTIBODIES TO A TRANSGENIC SELF ANTIGEN EXPRESSED IN PANCREATIC BETA-CELLS
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DOI：
10.1038/325223a0
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发表时间：
1987-01-15
期刊：
影响因子：
64.8
通讯作者：
HANAHAN, D
中科院分区：
文献类型：
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作者：
ADAMS, TE;ALPERT, S;HANAHAN, D
在胰岛素基因调控区控制下表达猴病毒40t抗原的转基因小鼠对该蛋白的反应不同。每个谱系的特点是要么耐受T抗原，要么不耐受，在这种情况下，自身抗体出现频率很高，淋巴细胞浸润并破坏胰岛。非耐受性和自身免疫反应似乎都是由于β细胞发育过程中T抗原表达延迟的结果。
Transgenic mice expressing simian virus 40 T antigen under control of the insulin gene regulatory region vary in their response to this protein. Each lineage is characteristically either tolerant to T antigen, or not, in which case autoantibodies arise with high frequency, and lymphocytes infiltrate and disrupt the pancreatic islets. Both non-tolerance and the autoimmune response appear to result from delayed onset of T antigen expression during β cell development.