MATERNAL AGE-SPECIFIC RATES OF NUMERICAL CHROMOSOME-ABNORMALITIES WITH SPECIAL REFERENCE TO TRISOMY
MATERNAL AGE-SPECIFIC RATES OF NUMERICAL CHROMOSOME-ABNORMALITIES WITH SPECIAL REFERENCE TO TRISOMY
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DOI：
10.1007/bf00389450
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发表时间：
1985-01-01
期刊：
影响因子：
5.3
通讯作者：
CHIU, D
中科院分区：
文献类型：
--
作者：
HASSOLD, T;CHIU, D
在所有临床确认的人类妊娠中，评价了母亲年龄对染色体正常自然流产和不同类型染色体异常发生率的影响。结果没有提供年龄与性染色体单体性或多倍性显著相关的证据，但清楚地表明年龄对三体性和染色体正常自然流产频率的影响。计算了所有公认的妊娠中估计的母体年龄特异性三体率，并表明40岁及以上妇女的大多数卵母细胞可能是非整倍体。
The effect of maternal age on the incidence of chromosomally normal spontaneous abortion and different categories of chromosome abnormality among all clinically recognized human pregnancies was evaluated. The results provide no evidence for a significant association of age with sex chromosome monosomy or polyploidy, but clearly demonstrate an effect of age on the frequency of trisomy and chromosomally normal spontaneous abortions. Estimated maternal age-specific rates of trisomy among all recognized pregnancies were calculated and suggest that a majority of oocytes of women aged 40 yr and older may be aneuploid.