HOMOLOGY OF CYTOKINE SYNTHESIS INHIBITORY FACTOR (IL-10) TO THE EPSTEIN-BARR-VIRUS GENE BCRFI
HOMOLOGY OF CYTOKINE SYNTHESIS INHIBITORY FACTOR (IL-10) TO THE EPSTEIN-BARR-VIRUS GENE BCRFI
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DOI：
10.1126/science.2161559
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发表时间：
1990-06-08
期刊：
影响因子：
56.9
通讯作者：
MOSMANN, TR
中科院分区：
文献类型：
--
作者：
MOORE, KW;VIEIRA, P;MOSMANN, TR
编码小鼠细胞因子合成抑制因子（CSIF；白介素-10）的互补 DNA 克隆被分离和表达，该因子抑制 TH1 辅助 T 细胞的细胞因子合成。预测的蛋白质序列与 Epstein-Barr 病毒基因中未表征的开放阅读框 BCRFI 显示出广泛的同源性，表明这种疱疹病毒可能利用捕获的细胞因子基因的生物活性来增强其在宿主中的存活率。
Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus gene, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.