EFFECT OF ANTIOXIDANTS ON ROTIFER LIFE-SPAN AND ACTIVITY
EFFECT OF ANTIOXIDANTS ON ROTIFER LIFE-SPAN AND ACTIVITY
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作者：
BOZOVIC, V;ENESCO, HE
抗氧化剂噻唑烷-4-羧酸 (TCA) 是一种硫氢基清除剂。研究发现，浓度为 400 或 800 uM 时，轮虫 Asplanchna bighwelli 的平均寿命显着延长 7.8%。 A. brightwelli 的最大寿命不受该药物的影响。丁基羟基甲苯（BHT）是一种真正的断链抗氧化剂，对轮虫有毒。维生素C是一种还原剂类抗氧化剂，对轮虫的寿命没有影响。虽然TCA使轮虫平均寿命显着增加，但并没有显着影响轮虫的活性水平。这里提出的结果与衰老的自由基理论一致。
The antioxidant thiazolidine-4-carboxylic acid (TCA) is a sulfhydryl scavenger. At concentrations of 400 or 800 uM it was found to significantly extend the mean lifespan of the rotifer Asplanchna brighwelli by 7.8%. Maximum lifespan of A. brighwelli was not influenced by this drug. Butylated hydroxytoluene (BHT), a true chain-breaking antioxidant, was toxic to the rotifers. Vitamin C, an antioxidant of the reducing agent category, had no effect on rotifer lifespan. Although TCA brought about a significant increase in mean rotifer lifespan, it did not significantly affect the activity level of the rotifers. The results presented here are consistent with the free radical theory of aging.