Assessment of myelination in hypomyelinating disorders by quantitative MRI
Assessment of myelination in hypomyelinating disorders by quantitative MRI
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DOI：
10.1002/jmri.23774
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发表时间：
2012-12-01
影响因子：
4.4
通讯作者：
Helms, G.
中科院分区：
文献类型：
--
作者：
Dreha-Kulaczewski, Steffi F.;Brockmann, Knut;Helms, G.
目的：在定义的髓鞘形成不足的情况下应用髓鞘敏感的定量磁共振成像（MRI）技术，并确定髓鞘形成的空间模式作为未定义疾病的表征标准。材料与方法：根据线粒体细胞病、Pelizaeus-Merzbacher病、GJA 12/GJC 2相关Pelizaeus-Merzbacher样病、髓鞘形成不足伴基底神经节和小脑萎缩、白质脑病伴共济失调、牙列延迟和髓鞘形成不足的诊断，纳入7例患者。对照组包括23名儿童和青少年（年龄范围2.6 - 22.4岁）。3 T MRI方案包括高分辨率T1和T2加权3D MRI、扩散张量（DTI）和磁化传递（MT）成像。平均扩散率、分数各向异性和MT饱和度的参数图显示为伪彩色叠加，并通过感兴趣区域和直方图分析进行评估。结果：结构MRI显示白色物质广泛的信号改变，但受到信号异质性的阻碍。定量DTI和MT反映了髓鞘化的程度和髓鞘化的判别模式出现在MT饱和图上。结论：定义的髓鞘形成不足条件下的定量参数提供了进一步分类未定义的白色物质疾病的额外标准。J.磁共振Imaging 2012; 36：13291338. (C)2012 Wiley Periodicals，Inc.
Purpose: To apply myelin-sensitive quantitative magnetic resonance imaging (MRI) techniques in defined hypomyelinating conditions and to identify spatial patterns of myelination as criteria for characterization of undefined disorders. Materials and Methods: Seven patients were included, based on the diagnosis of mitochondrial cytopathy, Pelizaeus-Merzbacher disease, GJA12/GJC2-related Pelizaeus-Merzbacher-like disease, hypomyelination with atrophy of the basal ganglia and cerebellum, and leukoencephalopathy with ataxia, delayed dentition, and hypomyelination. The control group comprised 23 children and adolescents (age range 2.622.4 years). The 3T MRI protocol consisted of high-resolution T1- and T2-weighted 3D MRI, diffusion tensor (DTI), and magnetization transfer (MT) imaging. Parameter maps of mean diffusivity, fractional anisotropy, and MT saturation were displayed as pseudocolor overlays and assessed by region-of-interest and histogram analysis. Results: Structural MRI revealed widespread signal alterations in white matter, but were hampered by signal heterogeneity. Quantitative DTI and MT reflected the degree of hypomyelination and discriminative patterns of myelination emerged on MT saturation maps. Conclusion: The quantitative parameters in the defined hypomyelination conditions provide additional criteria to further classify undefined white matter disorders. J. Magn. Reson. Imaging 2012; 36:13291338. (C) 2012 Wiley Periodicals, Inc.