The Arabidopsis circadian clock incorporates a cADPR-based feedback loop
The Arabidopsis circadian clock incorporates a cADPR-based feedback loop
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DOI：
10.1126/science.1146757
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发表时间：
2007-12-14
期刊：
影响因子：
56.9
通讯作者：
Webb, Alex A. R.
中科院分区：
文献类型：
--
作者：
Dodd, Antony N.;Gardner, Michael J.;Webb, Alex A. R.
转录反馈环是动物和植物生物钟的一个特征。我们发现，植物的昼夜节律钟也纳入胞质信号分子环腺苷二磷酸核糖（cADPR）。cADPR调节昼夜节律振荡器的转录反馈环并驱动Ca2+释放的昼夜节律振荡。cADPR信号传导的拮抗剂的作用、cADPR合成的操纵以及cADPR与生物钟相互作用的数学模拟表明，cADPR在植物生物钟内形成反馈回路。
Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.