Serum Levels of the Th1 Promoter IL-12 and the Th2 Chemokine TARC Are Elevated in Erythema Multiforme and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and Correlate with Soluble Fas Ligand Expression
Serum Levels of the Th1 Promoter IL-12 and the Th2 Chemokine TARC Are Elevated in Erythema Multiforme and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and Correlate with Soluble Fas Ligand Expression
复制标题
多形红斑和 Stevens-Johnson 综合征/中毒性表皮坏死松解症中 Th1 启动子 IL-12 和 Th2 趋化因子 TARC 的血清水平升高，并与可溶性 Fas 配体表达相关
作者：
P. Quaglino;M. Caproni;E. Antiga;E. del Bianco;S. Osella;P. Savoia;A. Frezzolini;D. Schena;A. Marzano;W. Volpi;C. De Simone;A. Parodi;P. Fabbri;M. Bernengo
背景：没有关于多形红斑 (EM) 和 Stevens-Johnson 综合征 (SJS)/中毒性表皮坏死松解症 (TEN) 中 Th2 趋化因子的数据。目的：评估 EM 和 SJS/TEN 中胸腺和活化调节趋化因子 (TARC)、巨噬细胞衍生趋化因子 (MDC) 和活化调节、正常 T 淋巴细胞表达和分泌趋化因子 (RANTES) 表达，并与 Th1 启动子白细胞介素 (IL)-12 和可溶性 Fas 配体 (sFasL) 的血清水平相关。材料和方法：通过 ELISA 技术分析 31 名未经治疗的 EM (n = 24) 或 SJS/TEN (n = 7) 患者和 28 名健康供体 (HD) 的 IL-12、sFasL、TARC、MDC 和 RANTES 表达。结果：与 HD 相比，EM 和 SJS/TEN 的 TARC、IL-12 和 sFasL 水平显着更高。 TARC 上调与 IL-12 (p = 0.0225) 和 sFasL 增加 (p = 0.0194) 平行。结论：我们的结果支持 TARC 在 EM/SJS/TEN 病理生理学中的作用，并证实除了主要的 Th1 谱外还存在 Th2 反应。
Background: No data exist as to Th2 chemokines in erythema multiforme (EM) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Objective: To evaluate thymus- and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and regulated upon activation, normal T-lymphocyte-expressed and secreted chemokine (RANTES) expression in EM and SJS/TEN and to correlate with the serum levels of the Th1 promoter interleukin (IL)-12 and soluble Fas ligand (sFasL). Materials and Methods: IL-12, sFasL, TARC, MDC and RANTES expression were analyzed by ELISA techniques in 31 untreated EM (n = 24) or SJS/TEN (n = 7) patients and in 28 healthy donors (HD). Results: EM and SJS/TEN exhibited significantly higher levels of TARC, IL-12 and sFasL with respect to HD. TARC upregulation paralleled both the IL-12 (p = 0.0225) and sFasL increase (p = 0.0194). Conclusions: Our results support a role of TARC in the pathophysiology of EM/SJS/TEN and confirm the coexistence of a Th2 response in addition to the predominant Th1 profile.
单纯疱疹病毒 (HSV) 相关多形红斑 (HAEM)：一种具有自身免疫成分的病毒性疾病。
DOI：
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发表时间：
2003
期刊：
Dermatology online journal [electronic resource].
影响因子：
--
作者：
Aurelian,L;Ono,F;Burnett,J
通讯作者：
Burnett,J
影响因子：
3.8
作者：
H. Fan;C. Walters;G. Dunston;R. Tackey
通讯作者：
H. Fan;C. Walters;G. Dunston;R. Tackey