CYP gene polymorphisms and early menarche
CYP gene polymorphisms and early menarche
复制标题
DOI：
10.1006/mgme.2001.3260
复制
发表时间：
2001-12-01
影响因子：
3.8
通讯作者：
Narod, SA
中科院分区：
文献类型：
--
作者：
Lai, J;Vesprini, D;Narod, SA
初潮年龄过早是乳腺癌的一个危险因素。先前的一项研究报告了CYP3A4*1B变异等位基因与青春期提前之间的显著正相关。我们研究了CYP3A4、CYP17、CYP1B1和CYP1A2基因多态性是否能预测初潮年龄。583名年龄在17岁至35岁之间的不同种族背景的未经产妇女完成了一份问卷调查，其中包括月经史的信息。提供DNA样本，并用于对这些妇女的四个基因中的多态性变体进行基因分型。携带两个变异CYP17 A2等位基因的女性（12.5岁）和携带一个或没有变异等位基因的女性（12.5岁）的初潮平均年龄无显著差异（P = 0.8，根据种族和出生年份进行调整）。对于CYP1B1*3变体等位基因和CYP1A2*1F变体等位基因，发现了相似的结果。携带两个变异CYP3A4*1B等位基因的女性初潮平均年龄（12.0岁）早于携带一个或没有变异等位基因的女性（12.6岁）（P = 0.02）。然而，调整种族和出生年份后，月经初潮的平均年龄没有显着差异，发现CYP3A4，CYP17，CYP1B1和CYP1A2基因的多态性变异不太可能影响月经初潮的年龄。(C)2001年，爱思唯尔科学。
Early age at menarche is a risk factor for breast cancer. A previous study reported a significant positive association between the CYP3A4*1B variant allele and early puberty. We investigated whether polymorphisms of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes predict the age at onset of menarche. Five hundred eighty-three nulliparous women between ages 17 and 35, of various ethnic backgrounds, completed a questionnaire that included information about menstrual history. Samples of DNA were provided and used to genotype these women for polymorphic variants in the four genes. There was no significant difference in mean age at menarche between women who carried two variant CYP17 A2 alleles (12.5 years) and women who carried one or no variant allele (12.5 years) (P = 0.8, adjusted for ethnic group and year of birth). Similar results were found for the CYP1B1*3 variant allele and for the CYP1A2*1F variant allele. Women who carried two variant CYP3A4*1B alleles had an earlier mean age at menarche (12.0 years) than women who carried one or no variant allele (12.6 years) (P = 0.02). However, after adjusting for ethnic group and year of birth, no significant differences in mean age at menarche were found. The polymorphic variants of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes are unlikely to influence age of menarche. (C) 2001 Elsevier Science.