Association of Japanese dietary pattern with serum adiponectin concentration in Japanese adult men
Association of Japanese dietary pattern with serum adiponectin concentration in Japanese adult men
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DOI：
10.1016/j.numecd.2010.06.006
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发表时间：
2012-03-01
影响因子：
3.9
通讯作者：
Nagatomi, R.
中科院分区：
文献类型：
--
作者：
Guo, H.;Niu, K.;Nagatomi, R.
背景和目的：尽管之前的研究表明日本传统饮食模式与较低的心血管疾病死亡率风险独立相关，但介导或联系这种关联的机制尚不清楚。脂联素已成为心血管疾病的有价值的生物标志物。本研究的目的是评估日本成年男性的饮食模式是否与血清脂联素浓度相关。方法和结果：我们设计了一项针对生活在日本的 702 名男性（中位[四分位距]年龄，44.5 [37.8-54.2]岁）的横断面研究。通过 75 项食物频率调查问卷评估饮食消耗。我们使用主成分分析从 39 个食物组中得出 3 种主要饮食模式：“日本”、“甜食水果”和“居酒屋（日本酒吧）”。使用特定的夹心酶联免疫吸附测定法测量血清脂联素浓度。调整潜在混杂因素后，与“日本”饮食模式因子评分三分位数相关的对数转换脂联素浓度的几何平均值（95% 置信区间）为最低三分位数为 5.24 (4.84-5.69)，中间三分位数为 5.82 (5.39-6.29)，最高三分位数为 5.95 (5.47-6.46)（趋势 P） < 0.01）。相比之下，“居酒屋”模式因子评分三分位数与脂联素浓度之间存在显着的负相关（趋势 P=0.03）。结论：日本成年男性对“日本”饮食模式的坚持与较高的血清脂联素浓度独立相关。这一发现支持了这样的假设：日本传统饮食可能对脂联素浓度具有潜在的有益影响。需要长期前瞻性研究或随机试验来阐明这种因果关系。 (C) 2010 Elsevier B.V. 保留所有权利。
Background and aims: Although previous studies suggest that the traditional Japanese dietary pattern is independently associated with a low cardiovascular disease mortality risk, the mechanisms mediating or linking this association are not well understood. Adiponectin has emerged as a valuable biomarker for cardiovascular diseases. The aim of present study was to evaluate whether dietary patterns are associated with serum adiponectin concentration in Japanese adult men.Methods and results: We designed a cross-sectional study of 702 men (median [interquartile range] age, 44.5 [37.8-54.2] years) living in Japan. Dietary consumption was assessed via a 75-item food frequency questionnaire. We used principal-components analysis to derive 3 major dietary patterns-"Japanese", "sweets-fruits" and, "Izakaya (Japanese Pub)"-from 39 food groups. Serum adiponectin concentration was measured by using a specific sandwich enzyme-linked immunosorbent assay. After adjustment for potential confounders, the geometric mean (95% confidence interval) for log-transformed adiponectin concentration associated with "Japanese" dietary pattern factor score tertiles were 5.24 (4.84-5.69) for the lowest tertile, 5.82 (5.39-6.29) for the middle tertile, and 5.95 (5.47-6.46) for the highest tertile (P for trend < 0.01). In contrast, a significant inverse association was found between the "Izakaya" pattern factor score tertiles and adiponectin concentration (P for trend=0.03).Conclusions: Greater adherence to the "Japanese" dietary pattern was independently associated to a higher serum adiponectin concentration in Japanese adult men. This finding supports the hypothesis that the traditional Japanese diet may have a potentially beneficial effect on adiponectin concentrations. A long-term prospective study or randomized trials are required to clarify this causality. (C) 2010 Elsevier B.V. All rights reserved.