p53; From inductive signal to cellular effect
p53; From inductive signal to cellular effect
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DOI：
10.1016/s0959-437x(97)80108-6
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发表时间：
1997-02-01
影响因子：
4
通讯作者：
Oren, M
中科院分区：
文献类型：
--
作者：
Hansen, R;Oren, M
在过去的一年里，p53如何抑制致癌作用的故事变得更加复杂。已经提供了进一步的洞察到潜在的p53的激活，参与生长停滞和凋亡的生化机制，以及各种信号对这些细胞效应的影响。此外，已经描述了p53在细胞衰老、抑制致畸和可能直接有助于维持基因组稳定性的过程中的作用。
During the past year, the story of how p53 suppresses carcinogenesis has increased in complexity. Further insight has been provided into the activation of latent p53, the biochemical mechanisms involved in growth arrest and apoptosis, and the influence of various signals on these cellular effects. Additionally, roles for p53 have been described in cell senescence, in suppressing teratogenesis, and in processes that may directly contribute to;he maintenance of genomic stability.