Subcellular localization of IRS-1 in cell proliferation and differentiation.
Subcellular localization of IRS-1 in cell proliferation and differentiation.
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IRS-1 在细胞增殖和分化中的亚细胞定位。
DOI：
10.1055/s-2004-814155
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Baserga,R
中科院分区：
文献类型：
--
作者：
Tu,X;Wu,A;Maiorana,A;Baserga,R
胰岛素样生长因子1型受体（IGF-IR）及其对接蛋白胰岛素受体底物1（IRS-1）在细胞转化、细胞分化和衰老中起重要作用。IRS-1和其他IRS蛋白在某些条件下可以定位于细胞核，在那里它们与核蛋白和核仁蛋白发生相互作用。在这项研究中，我们证实并扩展了这些观察结果，表明IRS-1在生长细胞中优先位于细胞核内。分化和核糖体RNA合成的抑制导致IRS-1和其他核蛋白向细胞质的亚细胞再分布。
The type 1 insulin-like growth factor receptor (IGF-IR) and its docking protein, insulin receptor substrate-1 (IRS-1), play important roles in cell transformation, cell differentiation and aging. IRS-1 and other IRS proteins can, under certain conditions, localize to the nuclei of cells, where they undergo interactions with nuclear and nucleolar proteins. In this study, we confirm and extend these observations, demonstrating that IRS-1 is preferentially nuclear in growing cells. Differentiation and inhibition of ribosomal RNA synthesis cause subcellular redistribution of IRS-1 and other nuclear proteins to the cytoplasm.