Impulse initiation and conduction in the murine atria: a basis for future investigation of sinus node dysfunction.
Impulse initiation and conduction in the murine atria: a basis for future investigation of sinus node dysfunction.
复制标题
小鼠心房的脉冲启动和传导：未来研究窦房结功能障碍的基础。
DOI：
10.1109/iembs.2005.1616356
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Morley,Gregory
中科院分区：
文献类型：
--
作者：
Baron,Elvera;Morley,Gregory
房室传导缺陷和窦房结功能障碍的患病率随着年龄的增长而增加。这些与年龄相关的变化可能在建立心房颤动(房颤)发展的底物方面发挥关键作用，房颤是最常见的持续性心律失常。尽管房性心律失常与年龄有关，但对房电生理功能改变的机制知之甚少。我们实验室正在进行的研究集中于确定与衰老和疾病相关的心房传导缺陷的机制。本报告的目的是介绍对小鼠窦房结的一些初步研究，以及我们已经采取的量化脉冲启动部位传导的方法。
The prevalence of atrial conduction defects and sinus node dysfunction increases with age. These age-related changes may play a critical role in establishing the substrate for the development of atrial fibrillation (AF), the most common sustained arrhythmia. Despite the association between atrial arrhythmias and age, little is known of the mechanisms that underlie changes in atrial electrophysiological function. Ongoing studies in our laboratory are focused on determining the mechanisms of atrial conduction defects associated with aging and disease. The purpose of this report is to present some initial studies of the murine sinus node and the approach we have taken to quantify conduction at the site of impulse initiation.