Primary osteosarcoma in elderly patients: A report of three cases
Primary osteosarcoma in elderly patients: A report of three cases
复制标题
老年原发性骨肉瘤三例报告
DOI：
10.3892/ol.2019.10446
复制
发表时间：
2019
期刊：
影响因子：
2.9
通讯作者：
Min Dai
中科院分区：
文献类型：
--
作者：
Qiang Xu;Tian Gao;Bin Zhang;Jin Zeng;Min Dai
骨肉瘤是儿童和年轻人中最常见的原发性恶性骨肿瘤。然而，原发性骨肉瘤在老年患者中是罕见的。本文报告3例老年晚期骨肉瘤。3例均经病理证实为原发性骨肉瘤。值得注意的是，每位患者都接受了不同的治疗选择。由于患者的年龄，建议在病例1中进行放化疗。但是，患者要求出院，失访。相反，在病例2中，62岁的女性患者接受了全身化疗，但没有手术治疗，在病例3中，51岁的男性患者接受了肿瘤完全切除术，并接受了晚期肿瘤复发的全身化疗。老年人骨肉瘤早期诊断困难，易误诊或漏诊。在临床实践中，应仔细研究老年患者的骨肿瘤。影像学检查对诊断是必不可少的，活检是必要的。然而，化疗对老年原发性骨肉瘤患者的疗效仍不确定。总的来说，由于老年人群中骨肉瘤的报告数量较少，本研究中的3例病例提高了对这种罕见疾病的认识。
Osteosarcoma is the most common type of primary malignant bone tumor in children and young adults. However, primary osteosarcoma in elderly patients is rare. The present study reports 3 cases of advanced osteosarcoma in elderly patients. The pathological findings in all 3 cases confirmed the diagnosis of primary osteosarcoma. Notably, each patient received different treatment options. Chemoradiotherapy was recommended in case 1 due to the age of the patient. However, the patient requested to be discharged and was lost to follow-up. Conversely, in case 2, the 62-year-old female patient underwent systemic chemotherapy, but no surgical treatment, and in case 3, the 51-year-old male patient underwent complete tumor resection and received systemic chemotherapy for late tumor recurrence. Early diagnosis of osteosarcoma in elderly patients is difficult, and misdiagnosis or a missed diagnosis is common. In clinical practice, bone tumors in elderly patients should be investigated carefully. Imaging examinations are essential for diagnosis, and biopsy is required for confirmation. However, the efficacy of chemotherapy for elderly patients with primary osteosarcoma remains uncertain. Collectively, due to the small number of reports of osteosarcoma in the elderly population, the 3 cases in the present study raise awareness of this rare condition.