Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies.
Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies.
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DOI：
10.4103/1673-5374.382220
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发表时间：
2024-04
影响因子：
6.1
通讯作者：
Koulen P
中科院分区：
文献类型：
--
作者：
Duncan RS;Riordan SM;Gernon MC;Koulen P
大麻素是来自大麻的亲脂性物质，可以在人体内发挥各种作用。它们已经在细胞和动物模型以及人类临床试验中进行了研究，以获得其在几种人类疾病中的治疗益处。其中一些包括中枢神经系统（CNS）疾病和功能障碍，例如癫痫、多发性硬化、帕金森病、疼痛和神经精神障碍。此外，内源性产生的大麻素脂质（endocannabinoids）对正常CNS功能至关重要，如果加以控制或修饰，可能代表CNS疾病的另一种治疗途径。这篇综述讨论了在体外细胞，离体组织和体内动物模型研究大麻素及其效用作为治疗多种中枢神经系统病变。此外，该综述还概述了大麻素在各种中枢神经系统疾病的人体临床试验中的应用。大麻素和内源性大麻素有望用作预防或治疗神经变性疾病和神经障碍的疾病调节剂和治疗剂。
Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human body. They have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human diseases. Some of these include central nervous system (CNS) diseases and dysfunctions such as forms of epilepsy, multiple sclerosis, Parkinson’s disease, pain and neuropsychiatric disorders. In addition, the endogenously produced cannabinoid lipids, endocannabinoids, are critical for normal CNS function, and if controlled or modified, may represent an additional therapeutic avenue for CNS diseases. This review discusses in vitro cellular, ex vivo tissue and in vivo animal model studies on cannabinoids and their utility as therapeutics in multiple CNS pathologies. In addition, the review provides an overview on the use of cannabinoids in human clinical trials for a variety of CNS diseases. Cannabinoids and endocannabinoids hold promise for use as disease modifiers and therapeutic agents for the prevention or treatment of neurodegenerative diseases and neurological disorders.
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影响因子：
13.8
作者：
O'Brien, Terence J.;Berkovic, Samuel F.;French, Jacqueline A.;Messenheimer, John A.;Sebree, Terri B.;Bonn-Miller, Marcel O.;Gutterman, Donna L.
通讯作者：
Gutterman, Donna L.
DOI：
10.1093/pm/pnaa303
发表时间：
2020-10-01
期刊：
Pain medicine (Malden, Mass.)
影响因子：
--
作者：
Chaves C;Bittencourt PCT;Pelegrini A
通讯作者：
Pelegrini A
影响因子：
6.2
作者：
Gorantla, Santhi;Makarov, Edward;Roy, Deepa;Finke-Dwyer, Jennifer;Murrin, L. Charles;Gendelman, Howard E.;Poluektova, Larisa
通讯作者：
Poluektova, Larisa
影响因子：
5.3
作者：
Berger, Maximus;Li, Emily;Amminger, G. Paul
通讯作者：
Amminger, G. Paul
影响因子：
6
作者：
Klotz KA;Grob D;Schönberger J;Nakamura L;Metternich B;Schulze-Bonhage A;Jacobs J
通讯作者：
Jacobs J