Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant
Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant
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DOI：
10.1248/bpb.25.1137
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发表时间：
2002-09-01
影响因子：
2
通讯作者：
Ohizumi, Y
中科院分区：
文献类型：
--
作者：
Nakatani, K;Atsumi, M;Ohizumi, Y
山竹（Garcinia mangostana L.）多年来一直被用作泰国本土药物。然而，其作为药物的作用机制尚未阐明。本研究旨在探讨山竹提取物（100%乙醇、70%乙醇、40%乙醇和水）对组胺释放和前列腺素E合成的影响。我们发现，山竹果的40%乙醇提取物抑制IgE介导的组胺从RBL-2 H3细胞中释放的效力大于日本已用作抗过敏生药的甜茶的水提取物。所有山竹果提取物均能有效抑制A23187诱导的C6大鼠胶质瘤细胞前列腺素E-2的合成，而甜茶水提取物则无此作用。山竹果40%乙醇提取物对前列腺素E2合成的抑制作用呈浓度依赖性，其浓度低于组胺释放。此外，这种乙醇提取物以及甜茶的水提取物对大鼠的被动皮肤过敏反应（PCA）有明显的抑制作用。这些结果表明，山竹果的40%乙醇提取物具有有效的抑制组胺释放和前列腺素E2合成的活性。
The fruit hull of mangosteen, Garcinia mangostana L. has been used as a Thai indigenous medicine for many years. However, its mechanism of action as a medicine has not been elucidated. The present study was undertaken to examine the effects of mangosteen extracts (100% ethanol, 70% ethanol, 40% ethanol and water) on histamine release and prostaglandin E, synthesis. We found that the 40% ethanol extract of mangosteen inhibited IgE-mediated histamine release from RBL-2H3 cells with greater potency than the water extract of Rubus suavissimus that has been used as an anti-allergy crude drug in Japan. All extracts of mangosteen potently inhibited A23187-induced prostaglandin E-2 synthesis in C6 rat glioma cells, while the water extract of Rubus suavissimus had no effect. The 40% ethanol extract of mangosteen inhibited the prostaglandin E2 synthesis in a concentration-dependent manner with relatively lower concentrations than the histamine release. In addition, passive cutaneous anaphylaxis (PCA) reactions in rats were significantly inhibited by this ethanol extract as well as by the water extract of Rubus suavissimus. These results suggest that the 40% ethanol extract of mangosteen has potent inhibitory activities of both histamine release and prostaglandin E2 synthesis.