TOR on the brain.
TOR on the brain.
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DOI：
10.1016/j.exger.2010.08.030
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发表时间：
2011-02
影响因子：
3.9
通讯作者：
Kennedy, Brian K.
中科院分区：
文献类型：
--
作者：
Garelick, Michael G.;Kennedy, Brian K.
Signaling by target of rapamycin (mTOR in mammals) has been shown to modulate lifespan in several model organisms ranging from yeast to mice. In mice, reduced mTOR signaling by chronic rapamycin treatment leads to lifespan extension, raising the possibility that rapamycin and its analogs may benefit the aging brain and serve as effective treatments of age-related neurodegenerative diseases. Here, we review mTOR signaling and how neurons utilize mTOR to regulate brain function, including regulation of feeding, synaptic plasticity and memory formation. Additionally, we discuss recent findings that evaluate the mechanisms by which reduced mTOR activity might benefit the aging brain in normal and pathological states. We will focus on recent studies investigating mTOR and Alzheimer s disease, Parkinson s disease, and polyglutamine expansion syndromes such as Huntington s disease.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
5.3
作者：
Banko, JL;Poulin, F;Klann, E
通讯作者：
Klann, E
影响因子：
56.9
作者：
Cota, D;Proulx, K;Seeley, RJ
通讯作者：
Seeley, RJ
影响因子：
4.7
作者：
Gobert, Delphine;Topolnik, Lisa;Lacaille, Jean-Claude
通讯作者：
Lacaille, Jean-Claude
影响因子：
29
作者：
Blouet, Clemence;Ono, Hiraku;Schwartz, Gary J.
通讯作者：
Schwartz, Gary J.