The role of the Wilms' tumour-suppressor protein WT1 in apoptosis
The role of the Wilms' tumour-suppressor protein WT1 in apoptosis
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DOI：
10.1042/bst0360629
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发表时间：
2008-08-01
影响因子：
3.9
通讯作者：
Roberts, Stefan G. E.
中科院分区：
文献类型：
--
作者：
Hartkamp, Joerg;Roberts, Stefan G. E.
Wilms肿瘤抑制基因（WT1）编码一种锌指转录因子，对包括肾脏、性腺和脾脏在内的几个器官的发育至关重要。尽管其被鉴定为在肾的儿科恶性肿瘤（Wilms'tumor）的形成中起关键作用的肿瘤抑制因子，但其也已作为影响多种成人癌症中的增殖和凋亡的致癌因子出现。本文综述了WT1在早期发展中的作用及其在成人癌症中的潜在致癌作用的新见解。
The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult cancer.