T regulatory lymphocytes in patients with endometriosis
T regulatory lymphocytes in patients with endometriosis
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DOI：
10.3892/mmr.2014.2294
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发表时间：
2014-08-01
影响因子：
3.4
通讯作者：
Adamiak, Aneta
中科院分区：
文献类型：
--
作者：
Gogacz, Marek;Winkler, Izabela;Adamiak, Aneta
本研究旨在探讨子宫内膜异位症患者外周血和腹腔液中调节性T细胞的存在情况。本研究纳入了2010年至2011年期间接受腹腔镜手术的42例患者。采用流式细胞术测定患者PF和PB中THP的百分比。在PF（9.1 +/- 5.4 vs. 9.1 +/- 3.8%）或PB（6.5 +/- 3.2 vs. 6.5 +/- 3.7%）中，与对照组相比，子宫内膜异位症组患者的THP百分比无显著差异。子宫内膜异位症组和对照组患者PF中TGFAP的百分比均高于PB，但仅在对照组中有显著性差异。此外，与晚期（III/IV）子宫内膜异位症患者相比，早期（I/II）子宫内膜异位症患者的Treg浓度无显著差异。此外，THBE百分比与患者的白色血细胞计数、淋巴细胞计数和CA 125浓度之间无显著相关性。这些发现表明，子宫内膜异位症患者的局部宿主防御机制是缺乏的，因此子宫内膜异位症不应该被视为一种自身免疫性疾病。
The present study aimed to investigate the presence of T regulatory cells (Tregs) in the peripheral blood (PB) and peritoneal fluid (PF) in females with endometriosis. The present study included 42 patients who underwent laparoscopy between 2010 and 2011. Flow cytometry was used to determine the percentage of Tregs in the PF and PB of the patients. No significant difference was observed in the percentage of Tregs in the patients in the endometriosis group compared with those in the control group in the PF (9.1 +/- 5.4 vs. 9.1 +/- 3.8%) or the PB (6.5 +/- 3.2 vs. 6.5 +/- 3.7%). However, the percentage of Tregs was found to be higher in the PF compared with the PB in the patients in the endometriosis and control groups, but significance was found only in those in the control group. Furthermore, no significant difference was observed in the Treg concentration in the patients with early stage (I/II) endometriosis compared with those with late stage (III/IV) endometriosis. Moreover, no significant correlation was found between the percentage of Tregs and the white blood cell count, lymphocyte count or CA125 concentration in the patients. These findings suggest that the local host-defense mechanism is deficient in patients with endometriosis, thus endometriosis should not be treated as an autoimmune condition.