Minimal activation of memory CD8+T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+T cells
Minimal activation of memory CD8+T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+T cells
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DOI：
10.1038/ni1505
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发表时间：
2007-10-01
影响因子：
30.5
通讯作者：
Heath, William R.
中科院分区：
文献类型：
--
作者：
Belz, Gabrielle T.;Bedoui, Sammy;Heath, William R.
在许多树突状细胞（DC）亚群中，表达单态性辅助受体CD8 α链（CD8 α）的DC永久定位于淋巴器官中，而“组织来源的DC”保留在非淋巴组织中，直到它们“捕获”抗原，然后移动到局部淋巴结。我们发现肺部感染后，初始和记忆性CD8（+）“杀伤”T细胞都对淋巴结驻留的CD8 α（+）DC呈递的流感病毒抗原有反应，但只有初始细胞对肺源性DC呈递的抗原有反应。这种差异提供了在稳健记忆占主导地位的条件下引发幼稚T细胞应答的机制。我们的研究结果对病原体的免疫力有影响，这些病原体可以突变其T细胞表位，如流感病毒和人类免疫缺陷病毒，并挑战长期持有的观点，即记忆T细胞对激活的要求不如幼稚T细胞严格。
Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8 alpha-chain (CD8 alpha) are localized permanently in lymphoid organs, whereas 'tissue-derived DCs' remain in nonlymphoid tissues until they 'capture' antigen and then move to local lymph nodes. Here we show that after lung infection, both naive and memory CD8(+) 'killer' T cells responded to influenza virus antigens presented by lymph node-resident CD8 alpha(+) DCs, but only naive cells responded to antigens presented by lung-derived DCs. This difference provides a mechanism for priming naive T cell responses in conditions in which robust memory predominates. Our findings have implications for immunity to pathogens that can mutate their T cell epitopes, such as influenza virus and human immunodeficiency virus, and challenge the long-held view that memory T cells have less-stringent requirements for activation than naive T cells have.