Maternal endotoxin exposure results in abnormal neuronal architecture in the newborn rabbit.
Maternal endotoxin exposure results in abnormal neuronal architecture in the newborn rabbit.
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DOI：
10.1159/000353156
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发表时间：
2013
影响因子：
2.9
通讯作者：
Kannan S
中科院分区：
文献类型：
--
作者：
Balakrishnan B;Dai H;Janisse J;Romero R;Kannan S
产妇宫内炎症/感染是导致早产儿和足月儿出现脑性瘫痪等神经系统疾病的潜在危险因素。脑性瘫痪与脑白质和灰质损伤有关。在目前的研究中，我们使用了一种脑性瘫痪的兔模型，在该模型中，怀孕的兔子被宫内注射内毒素脂多糖。然后，我们调查了新生儿工具包大脑中神经元损伤的程度。我们观察到1日龄兔脑前丘脑MAP2染色的神经元数量总体减少，而荧光玉C染色的细胞数量增加。我们还观察到，脾后皮质的分支点数量和脊椎密度总体上减少了，脾后皮质是丘脑前部参与认知和记忆的主要输出区。脾后皮质中棘突的丢失和树突萎缩可能是由于丘脑的突触前输入丢失所致。我们的研究表明，脑瘫患者的认知障碍可能与神经元的变性和丘脑和皮质神经元的异常树枝形成有关。
Maternal intrauterine inflammation/infection is a potential risk factor for the development of neurologic disorders such as cerebral palsy in preterm and term infants. Cerebral palsy is associated with white matter and grey matter injury. In the current study, we used a rabbit model of cerebral palsy in which pregnant rabbits are administered intrauterine injections of the endotoxin lipopolysaccharide. We then investigated the extent of neuronal damage in the newborn kit brain. We observed an overall decrease in number of MAP2-stained neurons and an increase in Fluoro-Jade C-stained cells in the anterior thalamus of 1-day-old rabbit brain. We also observed an overall decrease in the number of branching points and spine density in the retrosplenial cortex, a major output region of the anterior thalamus that is involved in cognition and memory. The loss of spines and dendritic atrophy in the retrosplenial cortex may be caused by loss of presynaptic input from the thalamus. Our study indicates that the cognitive impairments seen in patients with cerebral palsy may be related to degeneration of neurons and abnormal arborization of the thalamic and cortical neurons.
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影响因子：
3.8
作者：
Girard, Sylvie;Kadhim, Hazim;Sebire, Guillaume
通讯作者：
Sebire, Guillaume
DOI：
10.1016/j.ijdevneu.2011.02.011
发表时间：
2011-10
期刊：
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
影响因子：
--
作者：
Elovitz MA;Brown AG;Breen K;Anton L;Maubert M;Burd I
通讯作者：
Burd I
影响因子：
2.5
作者：
Billiards, Saraid S.;Haynes, Robin L.;Kinney, Hannah C.
通讯作者：
Kinney, Hannah C.
影响因子：
17.1
作者：
Kannan S;Dai H;Navath RS;Balakrishnan B;Jyoti A;Janisse J;Romero R;Kannan RM
通讯作者：
Kannan RM
影响因子：
3.9
作者：
Block, M. L.;Hong, J. -S.
通讯作者：
Hong, J. -S.