Marriage and parenthood among childhood cancer survivors: a report from the Italian AIEOP Off-Therapy Registry
Marriage and parenthood among childhood cancer survivors: a report from the Italian AIEOP Off-Therapy Registry
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DOI：
10.3324/haematol.2010.036129
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发表时间：
2011-05-01
期刊：
影响因子：
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通讯作者：
Pastore, Guido
中科院分区：
文献类型：
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作者：
Pivetta, Emanuele;Maule, Milena M.;Pastore, Guido
BackgroundThe的目的，这项研究是描述的模式，婚姻和父母在队列的儿童癌症幸存者包括在关闭治疗登记处维持的意大利协会的儿科血液学和Oncology.Design和MethodsWe分析了一个队列的6,044例患者诊断为癌症之间的1960年和1998年，年龄在0至14岁之间，到2003年12月年满18岁或以上。通过区域生命统计登记册对其进行随访，直至死亡或随访结束（2006年10月30日），以先发生者为准，并记录其婚姻状况和子女出生日期。按性别计算结婚和生育第一个孩子的累积概率，并按队列中的肿瘤类型进行比较。婚姻和生育率（后者定义为每名妇女每年活产的数量）进行了比较，与意大利人口的相同年龄，性别，居住区和日历期间的观察到的预期（O/E）ratio.ResultsDuring随访期间，4,633（77%）受试者没有结婚。男性和女性的婚姻O/E比值分别为0.56（95%CI：0.51-0.61）和0.70（95%CI：0.65-0.76）。总体而言，263名男子有367名活产婴儿，473名妇女有697名活产婴儿。女性生育率O/E比为0.57（95%CI：0.53-0.62）的整体，和1.08（95%CI：0.99-1.17）时，分析仅限于已婚/同居womenConclusionsChildhood癌症幸存者不太可能结婚，生孩子比一般人群，证实了他们以前的疾病对他们的社会行为和选择的终身影响。将咨询纳入儿童癌症患者的管理和长期监测策略中可能对接近成年的幸存者有益。
BackgroundThe aim of this study was to describe the patterns of marriage and parenthood in a cohort of childhood cancer survivors included in the Off-Therapy Registry maintained by the Italian Association of Pediatric Hematology and Oncology.Design and MethodsWe analyzed a cohort of 6,044 patients diagnosed with cancer between 1960 and 1998, while aged 0 to 14 years and who were 18 years old or older by December 2003. They were followed up through the regional vital statistics registers until death or the end of follow up (October 30, 2006), whichever occurred first, and their marital status and date of birth of their children were recorded. The cumulative probabilities of being married and having a first child were computed by gender and compared by tumor type within the cohort. Marriage and fertility rates (the latter defined as the number of live births per woman-year) were compared with those of the Italian population of the same age, gender, area of residence and calendar period by means of the observed to expected (O/E) ratios.ResultsDuring the follow-up period, 4,633 (77%) subjects had not married. The marriage O/E ratios were 0.56 (95% CI: 0.51-0.61) and 0.70 (95% CI: 0.65-0.76) among men and women, respectively. Overall, 263 men had 367 liveborn children, and 473 women had 697 liveborn children. The female fertility O/E ratio was 0.57 (95% CI: 0.53-0.62) overall, and 1.08 (95% CI: 0.99-1.17) when analyses were restricted to married/cohabiting womenConclusionsChildhood cancer survivors are less likely to marry and to have children than the general population, confirming the life-long impact of their previous disease on their social behavior and choices. The inclusion of counseling in the strategies of management and long-term surveillance of childhood cancer patients could be beneficial to survivors as they approach adulthood.