Dysregulated expression of long noncoding RNAs in gynecologic cancers.
Dysregulated expression of long noncoding RNAs in gynecologic cancers.
复制标题
DOI：
10.1186/s12943-017-0671-2
复制
发表时间：
2017-06-21
期刊：
影响因子：
37.3
通讯作者：
Asemi Z
中科院分区：
文献类型：
--
作者：
Hosseini ES;Meryet-Figuiere M;Sabzalipoor H;Kashani HH;Nikzad H;Asemi Z
女性生殖系统的癌症包括卵巢癌、子宫癌、阴道癌、子宫颈癌和外阴癌，这些癌症被称为妇科癌症。长链非编码rna （lncRNAs）被认为在几个不同的生物过程中起着至关重要的作用，它的出现使得基因表达的调控变得更加复杂。尽管lncrna的功能仍然难以捉摸，但它们在各种癌症的发生和进展中的广泛参与是清楚的。它们还参与了女性生殖系统癌症的发病机制。LncRNAs在这些肿瘤的凋亡、转移、侵袭、迁移和细胞增殖中发挥着重要的生理作用。lncRNAs在不同类型肿瘤中与正常组织、恶性肿瘤与良性肿瘤之间的表达谱存在差异。这些差异表达模式可能导致促进或抑制癌症的发展和肿瘤发生。在当前的综述中，我们提出了在卵巢癌、宫颈癌和子宫内膜癌的癌组织和正常组织中表现出差异表达的lncRNAs，并强调了lncRNAs与这些癌症中涉及的一些分子通路之间的关联。
Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed to play a crucial role in several different biological processes, has made the regulation of gene expression more complex. Although the function of lncRNAs is still rather elusive, their broad involvement in the initiation and progression of various cancers is clear. They are also involved in the pathogenesis of cancers of the female reproductive system. LncRNAs play a critical physiological role in apoptosis, metastasis, invasion, migration and cell proliferation in these cancers. Different expression profiles of lncRNAs have been observed in various types of tumors compared with normal tissues and between malignant and benign tumors. These differential expression patterns may lead to the promotion or suppression of cancer development and tumorigenesis. In the current review, we present the lncRNAs that show a differential expression between cancerous and normal tissues in ovarian, cervical and endometrial cancers, and highlight the associations between lncRNAs and some of the molecular pathways involved in these cancers.