Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle.
Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle.
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自灌注骨骼肌收缩过程中耗氧量的动力学控制。
DOI：
10.1113/jphysiol.2010.203422
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Rossiter,HarryB
中科院分区：
文献类型：
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作者：
Wust,RobCI;Grassi,Bruno;Hogan,MichaelC;Howlett,RichardA;Gladden,LBruce;Rossiter,HarryB
非技术性总结维持运动的能力取决于将由氧气提供的肌肉能量供应与活动的能量需求相匹配的能力（生物能量的“货币”被称为ATP）。在试管中使用肌肉样本的实验表明，肌肉耗氧量的激活是由ADP（ATP的分解产物）的积累引起的，这表明需要增加ATP供应。然而，这种体内信号传导过程的机制尚不清楚。我们研究了机制控制氧化ATP供应激活犬肌肉，同时测量耗氧量和ADP在肌肉收缩的开始。在收缩开始时，肌肉耗氧量的增加比从ADP的测量积累预测更快。这些数据表明，额外的过程（或过程）发生激活肌肉氧化ATP供应在运动开始时在体内。
Non‐technical summaryThe ability to sustain exercise is dependent on the ability to match muscular energy supply fuelled by oxygen to the energy demands of the activity (the ‘currency’ of biological energy is termed ATP). Experiments using muscle samples in a test tube suggest that the activation of muscle oxygen consumption is caused by accumulation of ADP (a breakdown product of ATP), which signals the need to increase ATP supply. The mechanism of this signalling processin vivo, however, is not well understood. We investigated the mechanism controlling oxidative ATP supply activation in canine muscle, by simultaneous measurements of oxygen consumption and ADP at the onset of muscle contractions. At the start of contractions muscle oxygen consumption increased more rapidly than predicted from the measured accumulation of ADP. These data suggest that an additional process (or processes) occurs to activate muscle oxidative ATP provision at the onset of exercisein vivo.