Effects of perchlorate exposure on resting metabolism, peak metabolism, and thyroid function in the prairie vole (Microtus ochrogaster)
Effects of perchlorate exposure on resting metabolism, peak metabolism, and thyroid function in the prairie vole (Microtus ochrogaster)
复制标题
高氯酸盐暴露对草原田鼠（Microtus ochrogaster）静息代谢、峰值代谢和甲状腺功能的影响
DOI：
10.1897/04-306r.1
复制
发表时间：
2005
影响因子：
4.1
通讯作者：
Philip N. Smith
中科院分区：
文献类型：
--
作者：
J. Isanhart;F. McNabb;Philip N. Smith
众所周知，大多数固体火箭推进剂配方中的氧化剂成分高氯酸盐会抑制甲状腺对碘的吸收，从而减少甲状腺激素三碘甲腺原氨酸和甲状腺素(T4)的产生。甲状腺激素调节吸热生物的新陈代谢，并负责维持恒温的体温。关于高氯酸盐对代谢能力的影响，人们知之甚少。本研究的目的是确定成年雄性草原田鼠(Microtus Ochrogaster)亚慢性(51d；0、1和10 mg/kg/d)和慢性(180 d；0.75 mg/kg/d)高氯酸盐暴露是否会由于循环甲状腺激素浓度下降而改变静息代谢率，并确定高氯酸盐暴露是否扰乱了冷应激下哺乳动物的产热。暴露在高氯酸盐中51天或180天的田鼠在暴露期间的任何时间点的静息代谢率都没有显著的变化。此外，治疗对峰值代谢率或血浆甲状腺激素浓度没有影响。然而，接触高氯酸盐的田鼠的甲状腺T4浓度显著低于对照组，这表明甲状腺T4含量可能是评估高氯酸盐暴露的更敏感的终点。总体而言，本研究没有提供与高氯酸盐暴露有关的能量变化的证据，高氯酸盐的浓度高于环境中地下水或地表水的典型浓度。
Perchlorate, the oxidizer component in most solid rocket propellant formulations, is known to inhibit the uptake of iodide into the thyroid gland, thereby reducing production of the thyroid hormones, triiodothyronine and thyroxine (T4). Thyroid hormones regulate metabolism in endothermic organisms and are responsible for maintenance of homeothermic body temperatures. Little is known about the effects of perchlorate on metabolic capacity. The objectives of the present study were to determine if subchronic (51 d; 0, 1, and 10 mg/kg/d) and chronic (180 d; 0.75 mg/kg/d) perchlorate exposure in adult male prairie voles (Microtus ochrogaster) would alter resting metabolic rates as a result of decreased circulating thyroid hormone concentrations and to determine if perchlorate exposure disrupts thermogenesis in mammals exposed to cold stress. Voles exposed to perchlorate for 51 or 180 d experienced no significant alterations in resting metabolic rates at any point during the exposure period. Additionally, the treatment had no effect on peak metabolic rates or plasma thyroid hormone concentrations. However, thyroid gland T4 concentrations were significantly lower in perchlorate‐exposed voles than in controls, indicating that thyroid gland T4 content may be a more sensitive endpoint than other thyroid variables for assessing perchlorate exposure. Overall, the present study did not provide evidence for energetic alterations associated with perchlorate exposure at concentrations that are higher than those typically found in groundwater or surface water in the environment.
DOI：
10.1016/s0300-595x(84)80039-0
发表时间：
1984-01-01
期刊：
CLINICS IN ENDOCRINOLOGY AND METABOLISM
影响因子：
--
作者：
DANFORTH, E;BURGER, A
通讯作者：
BURGER, A