Local Cerebral Blood Volume Response to Carbon Dioxide in Man
Local Cerebral Blood Volume Response to Carbon Dioxide in Man
复制标题
人体局部脑血容量对二氧化碳的反应
DOI：
10.1097/00004728-197811000-00046
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发表时间：
1978
影响因子：
20.1
通讯作者：
B. Uzzell
中科院分区：
文献类型：
--
作者：
J. Greenberg;A. Alavi;M. Reivich;D. Kuhl;B. Uzzell
本文应用发射断层扫描仪，对正常清醒人的脑灰质和白色区的局部脑血容量（LCBV）和动脉血二氧化碳分压（Pacoj）进行了三维测量，比较了静息状态下LCBV的大小及各区域之间的敏感性差异。在所研究的PacO 2范围内（20-42 μ l），灰质和白色物质对二氧化碳的响应均呈线性。灰质的LCBV对Paco 2变化的敏感性为0.053 ml/100 g/μ Paco 2，而在白色物质中，该敏感性为0.046 ml/100 g/μ Paco 2。发现这些灵敏度没有显著差异，整个大脑的LCBV-PacO 2曲线的斜率为0.049 ml/100 g/cm 2 PacO 2。这与整个大脑的其他数据非常一致。在Paco 2为34.4 mmHg（受试者的平均静息动脉二氧化碳分压）时，灰质的静息脑血容量为5.0 ml/100 g，显著高于白色物质的3.6 ml/100 g。在局部水平上，额叶皮质的脑血容量显著小于丘脑的脑血容量，而侧裂区域的额顶叶皮质的局部脑血容量显著大于丘脑的脑血容量。
We used an emission tomographic brain scanner to investigate the relationship between local cerebral blood volume (LCBV) and arterial blood carbon dioxide tension (Pacoj) in normal awake man. Measurements were made separately in three dimensions in various regions of grey and white matter, and the resting LCBV as well as the difference in sensitivity among these regions were compared. Over the range of PacO2 studied (20-42 torr), the response of both the grey matter and the white matter to carbon dioxide was linear. The LCBV sensitivity of the grey matter to changes in Paco2 was 0.053 ml/100 g per torr Paco2 and in the white matter this sensitivity was 0.046 ml/100 g per torr Paco2. These sensitivities were found not to be significantly different, yielding a slope of 0.049 ml/100 g per torr PacO2 for the LCBV-PacO2 curve for the entire brain. This is in excellent agreement with the other data for the whole brain. The resting cerebral blood volume of the grey matter at a Paco2 of 34.4 torr, which was the average resting arterial carbon dioxide tension of the subjects, was 5.0 ml/100 g and was significantly higher than for white matter, which was 3.6 ml/100 g. At the local level, the cerebral blood volume of the frontal cortex is significantly less than that of the thalamus, whereas the frontoparietal cortex in the region of the sylvian fissure has a local cerebral blood volume significantly greater than that of the thalamus.