ASIP genetic variants and the number of non-melanoma skin cancers.
ASIP genetic variants and the number of non-melanoma skin cancers.
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ASIP 遗传变异和非黑色素瘤皮肤癌的数量。
DOI：
10.1007/s10552-010-9724-1
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Han,Jiali
中科院分区：
文献类型：
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作者：
Lin,Wen;Qureshi,AbrarA;Kraft,Peter;Nan,Hongmei;Guo,Qun;Hu,FrankB;Jensen,MajkenK;Han,Jiali
患有原发性非黑色素瘤皮肤癌（NMSC）的患者倾向于在多个独立部位发展这些癌症。我们研究了遗传因素在发展中的多个NMSC的高加索妇女与28年的随访。我们最初评估了9个色素沉着基因中的19个SNP，其中492例病例和619例无NMSC病史的对照组的NMSC数量。我们发现两个ASIP基因相关的SNPs，rs 1885120和rs 910873，以及ASIP单倍型（AH）（rs 4911414等位基因T和rs 1015362等位基因G）与NMSC数量增加之间存在名义上的显著相关性，p值分别为0.008、0.01和0.01。我们在三个数据集中进一步评估了这两个SNP和AH单倍型。在对1,507例病例和4,335例对照的联合分析中，AH单倍型与NMSC数量独立相关，比值比（OR）（95%置信区间（CI））为1.45（1.25-1.68）（p值= 6.2E-07）。AH单倍型与发生一个NMSC的风险增加相关（OR 1.32; 95%CI，1.07-1.63）。对于具有2-4个NMSC的患者，OR增加到1.45（1.18-1.78），对于具有至少5个NMSC的患者，OR增加到1.84（1.34-2.53）。结果提示，ASIP位点与NMSCs的数量有关。
Patients with primary non-melanoma skin cancers (NMSCs) tend to develop these cancers at multiple independent sites. We examined the genetic factors in the development of multiple NMSCs among Caucasian women with 28 years of follow-up. We initially evaluated 19 SNPs in nine pigmentation genes with the number of NMSCs in 492 cases and 619 controls without a history of NMSC. We found nominal significant associations between twoASIPgene–related SNPs, rs1885120 and rs910873, and anASIPhaplotype (AH) (rs4911414 allele T and rs1015362 allele G) and an increased number of NMSCs, withp-values of 0.008, 0.01, and 0.01, respectively. We further evaluated these two SNPs and AH haplotype in three data sets. In a joint analysis with 1,507 cases and 4,335 controls, AH haplotype was independently associated with the number of NMSCs with odds ratio (OR) (95% confidence interval (CI)) of 1.45(1.25–1.68) (p-value = 6.2E–07). The AH haplotype was associated with an increased risk of developing one NMSC (OR 1.32; 95% CI, 1.07–1.63). The OR increased to 1.45(1.18–1.78) for those with 2–4 NMSCs and 1.84(1.34–2.53) for those with at least five. The findings suggest thatASIPlocus is associated with the number of NMSCs.