Cyclic exposure to ozone alters distal airway development in infant rhesus monkeys
Cyclic exposure to ozone alters distal airway development in infant rhesus monkeys
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DOI：
10.1152/ajplung.00027.2006
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发表时间：
2006-10-01
影响因子：
4.9
通讯作者：
Schelegle, Edward S.
中科院分区：
文献类型：
--
作者：
Fanucchi, Michelle V.;Plopper, Charles G.;Schelegle, Edward S.
暴露于高水平臭氧的内城儿童患呼吸道疾病的患病率增加。儿童的肺发育是一个长期的过程，在城市地区长大的儿童在发育过程中有一段相当长的时间暴露在氧化剂空气污染中。本研究旨在测试臭氧暴露事件引起的损伤和修复的重复循环是否会导致慢性气道疾病和通过改变正常肺成熟而降低肺功能。我们评估出生后的肺形态发生和功能的婴儿猴后，5个月的间歇性暴露的0.5百万分之一的臭氧开始在1个月的年龄。选择非人灵长类动物是因为它们的气道结构和出生后肺发育与人类相似。在5个月暴露期结束时评价气道形态和结构。与对照组婴儿相比，臭氧暴露的动物有四个较少的非肺泡化气道代，增生的细支气管上皮细胞，并改变平滑肌束方向的终端和呼吸细支气管。这些结果表明，间歇性暴露于环境臭氧损害出生后的气管支气管气道的形态发生。
Inner city children exposed to high levels of ozone suffer from an increased prevalence of respiratory diseases. Lung development in children is a long-term process, and there is a significant period of time during development when children growing up in urban areas are exposed to oxidant air pollution. This study was designed to test whether repeating cycles of injury and repair caused by episodes of ozone exposure lead to chronic airway disease and decreased lung function by altering normal lung maturation. We evaluated postnatal lung morphogenesis and function of infant monkeys after 5 mo of episodic exposure of 0.5 parts per million ozone beginning at 1 mo of age. Nonhuman primates were chosen because their airway structure and postnatal lung development is similar to those of humans. Airway morphology and structure were evaluated at the end of the 5-mo exposure period. Compared with control infants, ozone-exposed animals had four fewer nonalveolarized airway generations, hyperplastic bronchiolar epithelium, and altered smooth muscle bundle orientation in terminal and respiratory bronchioles. These results suggest that episodic exposure to environmental ozone compromises postnatal morphogenesis of tracheobronchial airways.