RESPIRATORY DEPRESSION BY MIDAZOLAM AND DIAZEPAM
RESPIRATORY DEPRESSION BY MIDAZOLAM AND DIAZEPAM
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DOI：
10.1097/00000542-198012000-00010
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发表时间：
1980-01-01
期刊：
影响因子：
8.8
通讯作者：
GEMPERLE, M
中科院分区：
文献类型：
--
作者：
FORSTER, A;GARDAZ, JP;GEMPERLE, M
测定了8名健康志愿者静脉滴注前后对CO2的通气量和口腔咬合压的反应。给予安定0.3 mg/kg和咪达唑仑0.15 mg/kg。对二氧化碳的平均通风反应(平均值+-。平均值的标准误差)在给予安定或咪达唑仑后从2.0±-下降。0.2至1.3+-L每分钟0.1分或从2.1.+-。0.2至1.4+-L/分钟分别为0.1%。在相同的志愿者中，口腔咬合压力反应从0.54.+-下降。0.05至0.30。+-。咪达唑仑后0.04 cm H2O/Torr，0.67±-。0.12至0.28。+-安定后0.07 cm H2O/Torr。与对照组相比，药物斜率有显著差异。在安定和咪达唑仑治疗后，呼吸同样受到抑制。静脉注射对二氧化碳的呼吸压力和口腔阻塞压力反应同样受到抑制。注射等剂量的咪达唑仑和安定表明这些药物直接抑制了中枢呼吸驱动。
Ventilatory and mouth occlusion pressure responses to CO2 were measured in 8 healthy human volunteers before and after the i.v. administration of 0.3 mg/kg of diazepam and 0.15 mg/kg of midazolam. The mean ventilatory response to CO2 (mean .+-. standard error of the mean) decreased after administration of diazepam or midazolam from 2.0 .+-. 0.2 to 1.3 .+-. 0.1 l/min torr or from 2.1 .+-. 0.2 to 1.4 .+-. 0.1 l/min torr, respectively. In the same volunteers, the mouth occlusion pressure responses decreased from 0.54 .+-. 0.05 to 0.30 .+-. 0.04 cm H2O/torr after midazolam and from 0.67 .+-. 0.12 to 0.28 .+-. 0.07 cm H2O/torr after diazepam. When compared with the control slopes of the ventilatory and mouth occlusion pressure responses, the drug slopes were significantly different. Respiration was similarly depressed after diazepam and after midazolam. That the ventilatory and mouth occlusion pressure responses to CO2 are equally depressed by i.v. injections of midazolam and of diazepam at equipotent doses suggests a direct depression of the central respiratory drive by these drugs.