Detection of Explosives and Related Compounds by Low-Temperature Plasma Ambient Ionization Mass Spectrometry
Detection of Explosives and Related Compounds by Low-Temperature Plasma Ambient Ionization Mass Spectrometry
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DOI：
10.1021/ac1029117
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发表时间：
2011-02-01
影响因子：
7.4
通讯作者：
Cooks, R. Graham
中科院分区：
文献类型：
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作者：
Garcia-Reyes, Juan F.;Harper, Jason D.;Cooks, R. Graham
爆炸物的检测对于公共安全非常重要。最近开发的一种用于在周围环境中解吸和电离样品的低温等离子体（LTP）探针（Anal. Chem. 2008, 80, 9097）用于快速检测13种爆炸物和爆炸物相关化合物的分析性能的综合评估。选定的化学品[季戊四醇四硝酸酯（PETN）、三硝基甲苯（TNT）、环1,3,5-三亚甲基三硝胺（RDX）、四硝基、环1,3,5,7-四亚甲基四硝酸酯（HMX）、六亚甲基三过氧化二胺（HMTD）、2,4-二硝基甲苯、1,3-二硝基苯、 1,3,5-三硝基苯、2-氨基-4,6-二硝基甲苯、4-氨基-2,6-二硝基甲苯、2,6-二硝基甲苯和4-硝基甲苯）的测试浓度范围为 1 pg-10 ng。大多数在负离子模式下表现出显着的灵敏度，检测限在低皮克范围内，特别是在加热至 120°C 的玻璃基板上进行分析时。这些分子 (M) 通常通过 LTP 形成的离子包括 [M + NO2](-)、[M](-) 和 [M - NO2](-)。 LTP 质谱方法显示，所研究爆炸物的分析物量超过三个数量级的线性信号响应。此外，还评估了合成基质和不同类型表面的影响。获得的数据表明 LTP-MS 可以检测超痕量爆炸物并确认其身份。使用串联质谱（MS/MS）来确认低含量的选定爆炸物的存在；例如，TNT 被证实绝对含量低至 0.6 皮克。还对线性度以及日内和日间精度进行了评估，得出的结果证明了 LTP-MS 在检测不同类别爆炸物方面的潜在实用性和耐用性。使用离子/分子反应与特定炸药（如 RDX 和 HMX）形成加合物已被证明可以增强选择性和特异性。这是通过将放电气体与适当的试剂顶空蒸气（例如来自 0.2% 三氟乙酸溶液）合并来实现的。
Detection of explosives is important for public safety. A recently developed low-temperature plasma (LTP) probe for desorption and ionization of samples in the ambient environment (Anal. Chem. 2008, 80, 9097) is applied in a comprehensive evaluation of analytical performance for rapid detection of 13 explosives and explosives-related compounds. The selected chemicals [pentaerythritol tetranitrate (PETN), trinitrotoluene (TNT), cyclo-1,3,5-trimethylenetrinitramine (RDX), tetryl, cyclo-1,3,5,7-tetramethylenetetranitrate (HMX), hexamethylene triperoxide diamine (HMTD), 2,4-dinitrotoluene, 1,3-dinitrobenzene, 1,3,5-trinitrobenzene, 2-amino-4,6-dinitrotoluene, 4-amino-2,6-dinitrotoluene, 2,6-dinitrotoluene, and 4-nitrotoluene) were tested at;levels in the range 1 pg-10 ng. Most showed remarkable sensitivity in the negative-ion mode, yielding limits of detection in the low picogram range, particularly when analyzed from a glass substrate heated to 120 degrees C. Ions typically formed from these molecules (M) by LTP include [M + NO2](-), [M](-) and [M - NO2](-). The LTP-mass spectrometry methodology, displayed, a linear signal response over three orders of magnitude of analyte amount for the studied explosives. In addition, the effects of synthetic matrices and different types of surfaces were evaluated. The data obtained demonstrate that LTP-MS allows detection of ultratrace amounts of explosives and confirmation of their identity. Tandem mass spectrometry (MS/MS) was used to confirm the presence of selected explosives at low levels; for example, TNT was confirmed at absolute levels as low as 0.6 pg. Linearity and intra- and interday precision were also evaluated, yielding results that demonstrate the potential usefulness and ruggedness of LTP-MS for the detection of explosives of different classes. The use of ion/molecule reactions to form adducts with particular explosives such as RDX and HMX was shown to enhance the selectivity and specificity. This was accomplished by merging the discharge gas with an appropriate reagent headspace vapor (e.g., from a 0.2% trifluoracetic acid solution).