Angiogenic Microspheres for the Treatment of a Thin Endometrium
Angiogenic Microspheres for the Treatment of a Thin Endometrium
复制标题
血管生成微球治疗子宫内膜变薄
DOI：
10.1021/acsbiomaterials.1c00615
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发表时间：
2021-08-20
影响因子：
5.8
通讯作者：
Yang, Lei
中科院分区：
文献类型：
--
作者：
Lei, Lanjie;Lv, Qizhuang;Yang, Lei
The poor vascular development of an endometrium is the key cause of a thin endometrium due to the vascular endothelial growth factor (VEGF) decreasing in the glandular epithelium. Hence, inducing angiogenesis is an effective strategy for thin endometrium treatment in clinic. Herein, we developed a novel angiogenic hydrogel microsphere based on methacrylated hyaluronic acid (HAMA) loaded with VEGF for the treatment of a thin endometrium by a microfluidic electrospray technique. The generated HAMA microspheres with uniform size, porous structure, and satisfactory biocompatibility increased the drug-loading ability and controlled the drug-release rate by adjusting the hydrogel concentration. Besides, the HAMA microspheres loaded with VEGF showed satisfactory biocompatibility and promoted blood vessel formation in vitro. More importantly, the combination of HA and VEGF promoted new blood vessels and endometrial regeneration of a thin endometrium in vivo. Therefore, the combination of HA and VEGF would be conducive to the development of a drugdelivery microsphere with excellent biocompatibility and therapeutic effect for thin endometrium treatment and other biomedical applications.
