Effects of Different Dietary and Lifestyle Modification Therapies on Metabolic Syndrome in Prediabetic Arab Patients: A 12-Month Longitudinal Study
Effects of Different Dietary and Lifestyle Modification Therapies on Metabolic Syndrome in Prediabetic Arab Patients: A 12-Month Longitudinal Study
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DOI：
10.3390/nu10030383
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发表时间：
2018-03-01
期刊：
影响因子：
5.9
通讯作者：
Al-Daghri, Nasser M.
中科院分区：
文献类型：
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作者：
Alfawaz, Hanan A.;Wani, Kaiser;Al-Daghri, Nasser M.
这项三组、随机、对照研究旨在确定一般建议（GA）对生活方式改变、强化生活方式改变计划（ILMP）和GA +二甲双胍的影响差异（GA + Met）在降低患有前驱糖尿病的受试者中的完全代谢综合征（MetS）的患病率中的作用; 294名沙特糖尿病前期患者（空腹血糖5.6-6.9 mmol/L）最初随机分组，263名完成6个月，237名完成12个月。他们被分为三组：GA组，接受标准的生活方式改变教育; ILMP，遵循严格的生活方式改变饮食和体力活动支持; GA + Met组。测量人体测量和生物化学估计。在基线、6个月和12个月时筛选完整MetS（主要终点）及其组分（次要终点）。ILMP组中的全MetS降低了26%（p < 0.001）; GA + Met组中降低了22.4%（p = 0.01），GA组中降低了8.2%（p = 0.28）。在ILMP和GA + Met组中，MetS组分的数量显著降低（平均变化分别为0.81，p < 0.001和0.35，p = 0.05）。组间比较显示，MetS成分在临床上显着减少，有利于ILMP组（-0.58（0.88-0.28），p < 0.001）。这项研究强调了ILMP与其他糖尿病预防方案相比在减少空腹血糖升高的沙特成年人MetS方面的临床效力。
This three-arm, randomized, controlled study aimed to determine the differences in the effects of general advice (GA) on lifestyle change, intensive lifestyle modification programme (ILMP) and GA + metformin (GA + Met) in reducing the prevalence of full metabolic syndrome (MetS) in subjects with prediabetes; 294 Saudis with prediabetes (fasting glucose 5.6-6.9 mmol/L) were initially randomized, 263 completed 6 months and 237 completed 12 months. They were allocated into three groups: GA group which received a standard lifestyle change education; ILMP which followed a rigorous lifestyle modification support on diet and physical activity; and a GA + Met group. Anthropometric and biochemical estimations were measured. Full MetS (primary endpoint) and its components (secondary endpoint) were screened at baseline, 6 and 12 months. Full MetS in the ILMP group decreased by 26% (p < 0.001); in GA + Met group by 22.4% (p = 0.01) and in GA group by 8.2% (p = 0.28). The number of MetS components decreased significantly in the ILMP and GA + Met groups (mean change 0.81, p < 0.001 and 0.35, p = 0.05, respectively). Between-group comparison revealed a clinically significant decrease in MetS components in favor of the ILMP group (-0.58 (0.88-0.28), p < 0.001). This study highlights the clinical potency of ILMP versus other diabetes prevention options in reducing MetS in Saudi adults with elevated fasting glucose.