Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
Accurate timing but increased impulsivity following excitotoxic lesions of the subthalamic nucleus.
复制标题
丘脑底核兴奋性毒性损伤后计时准确，但冲动性增加。
DOI：
10.1016/j.neulet.2008.05.071
复制
发表时间：
2008
影响因子：
2.5
通讯作者：
Matell,MatthewS
中科院分区：
文献类型：
--
作者：
Wiener,Martin;Magaro,ChristopherM;Matell,MatthewS
有几条证据表明，丘脑底核(STN)与需要精确的时间控制的行为有关。为了进一步研究这种可能性，我们训练大鼠执行峰值间隔(PI)计时任务[S.Roberts，Isolation of an Inside Clock，J.Exp.精神病患者。阿尼姆。B7(1981)242-268]，分10s和40s两个时程，然后用鹅膏油酸微量注射损毁STN。受损的动物能够维持精确的时间控制，但在试验后期无法抑制操作性反应，有时不太可能产生强化。这些结果表明，STN参与了冲动性或持续性反应抑制，但不参与时间加工。
Several lines of evidence have implicated the subthalamic nucleus (STN) in behaviors that require precise temporal control. In order to investigate this possibility further, we trained rats to perform a peak-interval (PI) timing task [S. Roberts, Isolation of an internal clock, J. Exp. Psychol. Anim. B 7 (1981) 242–268] with two durations (10s and 40s), and then lesioned the STN by microinjection of ibotenic acid. Lesioned animals were able to maintain precise temporal control, yet were unable to inhibit operant responses late in the trial, at times that were unlikely to yield reinforcement. These results indicate the involvement of the STN in impulsive or perseverative response inhibition, but not in temporal processing.