PHYSIOLOGICAL ACTIVATION OF A CORTICAL NETWORK DURING PERFORMANCE OF THE WISCONSIN CARD SORTING TEST - A POSITRON EMISSION TOMOGRAPHY STUDY
PHYSIOLOGICAL ACTIVATION OF A CORTICAL NETWORK DURING PERFORMANCE OF THE WISCONSIN CARD SORTING TEST - A POSITRON EMISSION TOMOGRAPHY STUDY
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DOI：
10.1016/0028-3932(95)00035-2
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发表时间：
1995-08-01
期刊：
影响因子：
2.6
通讯作者：
WEINBERGER, DR
中科院分区：
文献类型：
--
作者：
BERMAN, KF;OSTREM, JL;WEINBERGER, DR
威斯康星卡片分类测验（WCST）是一种传统上被认为对前额叶损伤敏感的神经心理学测验，为了确定在进行威斯康星卡片分类测验时所参与的神经回路，在年轻的正常受试者进行威斯康星卡片分类测验和执行特别设计的感觉运动控制任务时，用氧-15水和正电子发射断层扫描（PET）测量了局部脑血流量。为了考虑WCST PET扫描中涉及的各种认知操作和其他经验现象中哪些对生理激活模式至关重要，并将重点放在测试的工作记忆部分，在测试指导和标准练习后，对9名受试者进行了重复的WCST扫描。我们证实，WCST的表现涉及额叶皮层，也产生一个复杂的区域网络的激活，包括下顶叶，也涉及视觉关联和下颞叶皮层以及小脑的一部分。WCST在背外侧前额叶皮层（DLPFC）的激活即使在训练和练习后也保持显著，这表明工作记忆可能在很大程度上负责WCST期间DLPFC的生理反应，相反，DLPFC在调节工作记忆中起主要作用。
To determine the neural circuitry engaged by performance of the Wisconsin Card Sorting Test (WCST), a neuropsychological test traditionally considered to be sensitive to prefrontal lesions, regional cerebral blood flow was measured with oxygen-15 water and positron emission tomography (PET) while young normal subjects performed the test as well as while they performed a specially designed sensorimotor control task. To consider which of the various cognitive operations and other experiential phenomena involved in the WCST PET scan are critical for the pattern of physiological activation and to focus on the working memory component of the test, repeat WCST scans were also performed on nine of the subjects after instruction on the test and practice to criteria. We confirmed that performance of the WCST engages the frontal cortex and also produces activation of a complex network of regions consistently including the inferior parietal lobule but also involving the visual association and inferior temporal cortices as well as portions of the cerebellum. The WCST activation in the dorsolateral prefrontal cortex (DLPFC) remained significant even after training and practice on the test, suggesting that working memory may be largely responsible for the physiological response in DLPFC during the WCST and, conversely, that the DLPFC plays a major role in modulating working memory.