In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging
In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging
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DOI：
10.1359/jbmr.071116
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发表时间：
2008-04-01
影响因子：
6.2
通讯作者：
Majumdar, Sharmila
中科院分区：
文献类型：
--
作者：
Kazakia, Galateia J.;Hyun, Benedict;Majumdar, Sharmila
比较了两种非侵入性成像工具（3T MRI 和 HR-pQCT）获得的骨结构测量结果。检测到显着但中等的相关性以及参数值 2 至 4 倍的差异，这表明在解释这些成像方式的数据时必须考虑采集和分析的差异。简介：高场 MRI 和高分辨率 (HR)-pQCT 目前用于纵向骨结构研究。这些方式之间的采集和分析的巨大差异可能会影响产生的定量数据，并可能影响基于其结果的临床决策。我们的目标是比较通过 3T MRI 和 HR-pQCT 获得的体内小梁骨和皮质骨结构测量结果。材料和方法：本研究招募了绝经后骨质疏松女性 (n = 52)。使用 XtremeCT 扫描仪对桡骨和胫骨进行 HR-pQCT 3 成像，体素尺寸为 82 x 82 x 82 μm(3)。 MR 成像是在 3T Signa 扫描仪上使用 SSFP 成像序列进行的，像素大小为 156 x 156 μ m(2)，切片厚度为 500 μm。使用标准 HR-pQCT 和 MRI 分析技术计算结构参数。研究了 HR-pQCT、MRI 和 DXA 测量结果之间的关系。结果：HR-pQCT 和 MRI 参数之间存在显着相关性 (p < 0.0001)，并且 Tb.N (r(2) = 0.52)、Ct.Th (r(2) = 0.59) 和位点特异性 Tb.Sp (r(2) = 0.54-0.60）。 MRI 和 HR-pQCT 提供了统计上不同的结构参数值 (p < 0.0001)，其中 BV/TV 和 Tb.Th 表现出最大的差异 (MR/HR-pQCT = 3-4)。尽管 Tb.N 值的差异具有统计显着性，但平均差异与我们的再现性测量结果相当。观察到 MRI 和 HR-pQCT 分析程序之间的系统差异导致皮质厚度值存在差异，其中 MRI 值始终较高。在 MRI 或 HR-pQCT 参数与 DXA BMD 或 T 评分之间发现了最小的相关性，但桡骨处的 HR-pQCT 测量值和超远端桡骨 T 评分之间发现了中等相关性 (r(2) = 0.19-0.58)。 结论：这项研究为两种新兴的骨结构评估非侵入性工具提供了独特的见解。我们的研究结果强调了分析技术对体内评估结果的重大影响，并强调在解释这些模式的结果时考虑这些差异的重要性。
Bone structural measures obtained by two noninvasive imaging tools-3T MRI and HR-pQCT-were compared. Significant but moderate correlations and 2- to 4-fold discrepancies in parameter values were detected, suggesting that differences in acquisition and analysis must be considered when interpreting data from these imaging modalities.Introduction: High-field MRI and high resolution (HR)-pQCT are currently being used in longitudinal bone structure studies. Substantial differences in acquisition and analysis between these modalities may influence the quantitative data produced and could potentially influence clinical decisions based on their results. Our goal was to compare trabecular and cortical bone structural measures obtained in vivo by 3T MRI and HR-pQCT.Materials and Methods: Postmenopausal osteopenic women (n = 52) were recruited for this study. HR-pQCT 3 imaging of the radius and tibia was performed using the XtremeCT scanner, with a voxel size of 82 x 82 x 82 mu m(3). MR imaging was performed on a 3T Signa scanner using SSFP imaging sequences, with a pixel size of 156 x 156 mu m(2) and slice thickness of 500 mu m. Structure parameters were calculated using standard HR-pQCT and MRI analysis techniques. Relationships between measures derived from HR-pQCT, MRI, and DXA were studied.Results: Significant correlations between HR-pQCT and MRI parameters were found (p < 0.0001) and were strongest for Tb.N (r(2) = 0.52), Ct.Th (r(2) = 0.59), and site-specific Tb.Sp (r(2) = 0.54-0.60). MRI and HR-pQCT provided statistically different values of structure parameters (p < 0.0001), with BV/TV and Tb.Th exhibiting the largest discrepancies (MR/HR-pQCT = 3-4). Although differences in the Tb.N values were statistically significant, the mean differences were on the order of our reproducibility measurements. Systematic differences between MRI and HR-pQCT analysis procedures leading to discrepancies in cortical thickness values were observed, with MRI values consistently higher. Minimal correlations were found between MRI or HR-pQCT parameters and DXA BMD or T-score, except between HR-pQCT measures at the radius and the ultradistal radius T-scores, where moderate correlations were found (r(2) = 0.19-0.58).Conclusions: This study provides unique insight into two emerging noninvasive tools for bone structure evaluation. Our findings highlight the significant influence of analysis technique on results of in vivo assessment and underscore the importance of accounting for these differences when interpreting results from these modalities.