Translational Animal Models Provide Insight Into Mesenchymal Stromal Cell (MSC) Secretome Therapy.
Translational Animal Models Provide Insight Into Mesenchymal Stromal Cell (MSC) Secretome Therapy.
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DOI：
10.3389/fcell.2021.654885
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发表时间：
2021
影响因子：
5.5
通讯作者：
Van de Walle GR
中科院分区：
文献类型：
--
作者：
Harman RM;Marx C;Van de Walle GR
间充质基质细胞（MSC）分泌组，由MSC分泌的所有分子组成的治疗潜力被深入研究。骨髓间充质干细胞可以很容易地分离，扩大，并在文化中操纵，很少有人争论其收集的道德。尽管有前景的临床前研究，但大多数基于MSC分泌组的疗法尚未在人类医学中实施，部分原因是MSC分泌的生物活性因子的复杂性尚未完全了解。此外，MSC分泌组是可变的，受个体供体、组织来源、培养条件和传代的影响。增加对组成分泌组的因子的理解以及操纵MSC以持续分泌具有生物重要性的因子的能力将改善MSC治疗。为了帮助实现这一目标，我们可以从兽医物种分离的MSC分泌因子的丰富信息中获得。这些转化的动物模型将激发将人MSC分泌组治疗从实验室转移到床边的努力。
The therapeutic potential of the mesenchymal stromal cell (MSC) secretome, consisting of all molecules secreted by MSCs, is intensively studied. MSCs can be readily isolated, expanded, and manipulated in culture, and few people argue with the ethics of their collection. Despite promising pre-clinical studies, most MSC secretome-based therapies have not been implemented in human medicine, in part because the complexity of bioactive factors secreted by MSCs is not completely understood. In addition, the MSC secretome is variable, influenced by individual donor, tissue source of origin, culture conditions, and passage. An increased understanding of the factors that make up the secretome and the ability to manipulate MSCs to consistently secrete factors of biologic importance will improve MSC therapy. To aid in this goal, we can draw from the wealth of information available on secreted factors from MSC isolated from veterinary species. These translational animal models will inspire efforts to move human MSC secretome therapy from bench to bedside.
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