Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats
Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats
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DOI：
10.1016/j.ejphar.2012.11.012
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发表时间：
2013-01-15
影响因子：
5
通讯作者：
Prince, P. Stanely Mainzen
中科院分区：
文献类型：
--
作者：
Roy, Subhro Jyoti;Prince, P. Stanely Mainzen
脂类和脂蛋白在心肌梗死的发病机制中起着重要作用。芥子酸对心肌梗死患者心电图、血脂、脂蛋白变化的保护作用尚未见报道。本研究旨在评价芥子酸对异丙肾上腺素诱导的心肌梗死大鼠心肌肥厚、血脂异常及脂蛋白和心电图改变的保护作用。大鼠每日灌胃芥子酸(12 mg/kg体重)，连续给药10d，第9、10天给予异丙肾上腺素(100 mg/kg体重)诱发心肌梗死。异丙肾上腺素诱导的大鼠血清心肌肌钙蛋白-T水平升高，ST段抬高。异丙肾上腺素诱导的大鼠血清和心脏胆固醇、甘油三酯和游离脂肪酸水平升高。异丙肾上腺素还可升高血清低密度和极低密度脂蛋白胆固醇，降低高密度脂蛋白胆固醇。异丙肾上腺素诱导的大鼠肝脏3-羟基-3-甲基戊二酰辅酶A还原酶活力升高。体外实验表明芥子酸具有较强的抗氧化活性。芥子酸可改善异丙肾上腺素诱导的心肌梗死大鼠心肌肥厚、血脂异常和ST段抬高。因此，芥子酸通过其降脂作用预防异丙肾上腺素诱导的心肌梗死大鼠血脂和脂蛋白水平的变化。(C)2012爱思唯尔B.V.保留所有权利。
Lipids and lipoproteins play a vital role in the pathogenesis of myocardial infarction. There are no studies reported on the protective effects of sinapic acid on changes in electrocardiogram, lipids and lipoproteins in myocardial infarction. This study aims to evaluate the protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and alterations in lipoproteins and electrocardiogram in isoproterenol-induced myocardial infarcted rats. Rats were pre- and co-treated with sinapic acid (12 mg/kg body weight) daily for a period of 10 days and were induced myocardial infarction with isoproterenol (100 mg/kg body weight) on 9th and 10th day. Isoproterenol induced rats showed an increased level of serum cardiac troponin-T and elevated ST-segments. Increased levels of serum and heart cholesterol, triglycerides and free fatty acids were observed in isoproterenol induced rats. Isoproterenol also increased serum low density and very low density lipoprotein cholesterol and decreased high density lipoprotein cholesterol. The activity of liver 3-hydroxy-3-methyl glutaryl-coenzyme-A-reductase was elevated in isoproterenol induced rats. The in vitro study revealed the potent antioxidant activity of sinapic acid. Pre- and co-treatment with sinapic acid ameliorated cardiac hypertrophy, dyslipidemia and elevated ST-segments in isoproterenol induced myocardial infarcted rats. Thus, sinapic acid prevented the alterations in the levels of lipids and lipoproteins by virtue of its antilipidaemic effect in isoproterenol induced myocardial infarcted rats. (C) 2012 Elsevier B.V. All rights reserved.