Maternal Exposure to Synthetic Chemicals and Obesity in the Offspring: Recent Findings.
Maternal Exposure to Synthetic Chemicals and Obesity in the Offspring: Recent Findings.
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DOI：
10.1007/s40572-015-0068-6
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发表时间：
2015-12
影响因子：
7.9
通讯作者：
Peterson KE
中科院分区：
文献类型：
--
作者：
Liu Y;Peterson KE
Exposures to synthetic chemicals are among the environmental influences implicated in the development of obesity, given that changes in the genetic background cannot explain dramatic trends in recent decades. Experimental studies suggest perinatal exposures to so-called obesogens may be associated with increased risk of early onset obesity, although this hypothesis has not been extensively examined in humans. This article reviews the latest evidence supporting or refuting effects of maternal exposure to 11 common synthetic chemicals on child obesity during sensitive developmental periods. Twenty-two epidemiologic studies conducted since 2011 offer inconsistent support for the obesogenic effects of most substances and are limited by relatively small sample sizes and indirect measures of adiposity. The clearest findings suggest an influence of maternal DDE exposure on offspring overweight or obesity. We conclude with recommendations for future epidemiological research on the role of exposures in development of obesity in childhood.
