Lack of support for Deuterostomia prompts reinterpretation of the first Bilateria

Lack of support for Deuterostomia prompts reinterpretation of the first Bilateria
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缺乏对 Deuterostomia 的支持促使重新解释第一个 Bilateria

DOI:
10.1101/2020.07.01.182915
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发表时间:
2020
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影响因子:
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通讯作者:
Kapli P
Kapli P
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作者:
Kapli P

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两侧对称的动物(Bilateria)被认为包括两个单系类群,原口门(Ecdysozoa和Lophotrochozoa)和次口门(Chordata和Xenambulacraria)。最近的分子系统发育研究并不一致支持后口单系。在这里,我们比较支持Protostomia和Deuterostomia使用多个,独立的基因组数据集。正如预期的那样,Protostomia总是得到强有力的支持,特别是更长和更高质量的基因。然而,对后口虫的支持总是模棱两可的,仅仅高于对并系替代物的支持。导致树重建错误的条件不适当的模型,短的内部分支,更快地进化的基因,和不等的分支长度与支持单系后口动物相吻合。模拟实验表明,支持下口可以解释系统误差。两侧和后口共同祖先之间的分支充其量是非常短的,支持了两侧祖先可能是后口类的观点。我们的发现对理解早期动物进化具有重要意义。
The bilaterally symmetric animals (Bilateria) are considered to comprise two monophyletic groups, Protostomia (Ecdysozoa and the Lophotrochozoa) and Deuterostomia (Chordata and the Xenambulacraria). Recent molecular phylogenetic studies have not consistently supported deuterostome monophyly. Here, we compare support for Protostomia and Deuterostomia using multiple, independent phylogenomic datasets. As expected, Protostomia is always strongly supported, especially by longer and higher-quality genes. Support for Deuterostomia, however, is always equivocal and barely higher than support for paraphyletic alternatives. Conditions that cause tree reconstruction errors—inadequate models, short internal branches, faster evolving genes, and unequal branch lengths—coincide with support for monophyletic deuterostomes. Simulation experiments show that support for Deuterostomia could be explained by systematic error. The branch between bilaterian and deuterostome common ancestors is, at best, very short, supporting the idea that the bilaterian ancestor may have been deuterostome-like. Our findings have important implications for the understanding of early animal evolution.
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