Clinical parameter and Th17 related to lymphocytes infiltrating degree of labial salivary gland in primary Sjogren's syndrome
Clinical parameter and Th17 related to lymphocytes infiltrating degree of labial salivary gland in primary Sjogren's syndrome
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原发性干燥综合征临床参数及与唇唾液腺淋巴细胞浸润程度相关的Th17
DOI：
10.1007/s10067-013-2476-z
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发表时间：
2014-04-01
影响因子：
3.4
通讯作者：
Zhang, Fengchun
中科院分区：
文献类型：
--
作者：
Fei, Yunyun;Zhang, Wen;Zhang, Fengchun
本研究旨在探讨原发性干燥综合征（pSS）临床参数、Th17与唇唾液腺淋巴细胞浸润程度的相关性。对103例符合欧美共识分类标准的pSS患者进行小唇腺活检检查，根据唇唾液腺淋巴细胞浸润程度及生发中心形成情况分为G1 ~ G3组。同时分析54例pSS患者外周血IL-17水平和Th17比例。103份唇唾液腺样本中，G1占10.5%，G2占68.4%，G3占21.1%。一些临床参数与唇腺炎症细胞浸润程度有显著相关性，包括白细胞计数、淋巴细胞、肝酶和肺功能扩散率。IL-17的平均光密度与唇腺淋巴细胞浸润的严重程度相关，而外周血单个核细胞中Th17细胞的比例与SS患者唇腺淋巴细胞浸润的程度无显著关系。免疫抑制剂治疗前pSS患者外周血单个核细胞IL-17A mRNA水平明显高于免疫抑制剂治疗后患者。唇腺炎性细胞浸润程度与pSS的一些临床表现有关。IL-17可能在唇腺淋巴细胞浸润的发病机制中起作用。免疫抑制治疗可能影响Th17细胞。
The aim of this study is to investigate the correlation between clinical parameter, Th17, and degree of lymphocytes infiltrating in labial salivary gland in primary Sjogren's syndrome (pSS). Minor labial gland biopsies from a cohort of 103 patients fulfilling the American-European consensus classification criteria for pSS were examined and grouped into G1 to G3 according to infiltration degree of lymphocytes in labial salivary glands and formation of germinal center. IL-17 level and Th17 proportion of peripheral blood samples in 54 patients with pSS were analyzed simultaneously. Among the 103 labial salivary glands samples, there were 10.5 % of G1, 68.4 % of G2, and 21.1 % of G3, respectively. Some clinical parameters were markedly associated with the degree of inflammatory cells infiltration in labial glands, including white blood cell counts, lymphocytes, liver enzymes, and pulmonary function diffusion rates. The average optical density of IL-17 correlated with the severity of lymphocytic infiltration in the labial glands, while the proportion of Th17 cells in the peripheral blood mononuclear cells showed no significant relationship to the degree of lymphocytic infiltration in the labial glands from the SS patients. IL-17A mRNA levels in peripheral blood mononuclear cells from pSS patients before immunosuppressant treatment were significantly higher than that in patients after immunosuppressant treatment. The degree of inflammatory cells infiltration in labial glands was related to some clinical manifestations in pSS. IL-17 may play a role in the pathogenesis of lymphocytic infiltration in the labial glands. Immunosuppressive treatment might affect Th17 cells.