Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target.
Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target.
复制标题
趋化因子网络在卵巢癌发展和发展中的作用：潜在的新型药理靶标。
DOI：
10.1155/2010/426956
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发表时间：
2010
影响因子：
--
通讯作者：
Florio, Tullio
中科院分区：
文献类型：
--
作者：
Barbieri, Federica;Bajetto, Adriana;Florio, Tullio
卵巢癌是最常见的妇科恶性肿瘤。尽管手术和化疗取得了进展，但由于大多数卵巢癌复发并产生耐药性，生存率仍然很低。趋化因子是一类主要参与免疫应答的小分子化学引诱肽。最近，趋化因子也被证明可以调节额外的免疫功能。研究表明，趋化因子网络在多种组织的肿瘤发生中起着重要作用。特别地，CXCL 12及其受体CXCR 4的不平衡或异常表达强烈影响癌细胞增殖、免疫抑制细胞的募集、新血管形成和转移。在过去的几年中，已经开发了几种能够靶向CXCR 4或CXCL 12的分子来干扰肿瘤生长，包括药理学抑制剂，拮抗剂和特异性抗体。这种趋化因子配体/受体对也被提出代表用于治疗卵巢癌的创新治疗靶点。因此，对卵巢癌生物学的深入了解，以及趋化因子如何控制这些不同的生物活性，可能会导致更有效的治疗方法的发展。本文将重点介绍CXCL 12/CXCR 4轴的当前生物学，以了解它们在卵巢癌发展中的潜在作用。
Ovarian cancer is the most common type of gynecologic malignancy. Despite advances in surgery and chemotherapy, the survival rate is still low since most ovarian cancers relapse and become drug-resistant. Chemokines are small chemoattractant peptides mainly involved in the immune responses. More recently, chemokines were also demonstrated to regulate extra-immunological functions. It was shown that the chemokine network plays crucial functions in the tumorigenesis in several tissues. In particular the imbalanced or aberrant expression of CXCL12 and its receptor CXCR4 strongly affects cancer cell proliferation, recruitment of immunosuppressive cells, neovascularization, and metastasization. In the last years, several molecules able to target CXCR4 or CXCL12 have been developed to interfere with tumor growth, including pharmacological inhibitors, antagonists, and specific antibodies. This chemokine ligand/receptor pair was also proposed to represent an innovative therapeutic target for the treatment of ovarian cancer. Thus, a thorough understanding of ovarian cancer biology, and how chemokines may control these different biological activities might lead to the development of more effective therapies. This paper will focus on the current biology of CXCL12/CXCR4 axis in the context of understanding their potential role in ovarian cancer development.