The permeability of interstitial connective tissue and the nature of the interfibrillary substance
The permeability of interstitial connective tissue and the nature of the interfibrillary substance
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间质结缔组织的通透性和纤维间质的性质
DOI：
10.1113/jphysiol.1952.sp004728
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发表时间：
1952
期刊：
影响因子：
--
通讯作者：
T. D. Day
中科院分区：
文献类型：
--
作者：
T. D. Day
This communication is concerned with an experimental study of the permeability of interstitial connective tissue with particular reference to the mode of action of hyaluronidase. It has been suggested that hyaluronidase increases connective tissue permeability by the degradation of a mucopolysaccharide substance present in it (Chain & Duthie, 1940; Duran-Reynals, 1942, 1950). On the other hand, reasons have been given for the belief that the interfibrillary substance, upon which the permeability of the tissue must largely depend, consists predominantly of protein (Day, 1947a, b, 1949). The object of the present study is to resolve this apparent contradiction. The findings to be described suggest that the interfibrillary protein constitutes a net of small mesh in which macromolecules of sufficient size can be impacted, without regard to their precise chemical nature. If the meshes of this net are naturally occupied by molecules of hyaluronic acid, the contradiction is resolved.
