Factors affecting patient-reported outcomes after red blood cell transfusion in medical patients
Factors affecting patient-reported outcomes after red blood cell transfusion in medical patients
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DOI：
10.1111/trf.14397
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发表时间：
2018-01-01
期刊：
影响因子：
2.9
通讯作者：
Lee, Kwok Kuen Harold
中科院分区：
文献类型：
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作者：
Chan, Ka Lok Luke;Mak, Wai Man Vivien;Lee, Kwok Kuen Harold
研究背景：死亡率或心脏事件等物理变量被用来评估红细胞（RBC）输血的需求。然而，输血接受者的患者报告结果（PROs）很少被评估。本研究比较了输血前后患者的健康相关生活质量（HRQoL）。研究设计与方法研究时间为2016年2月至6月。对在单一中心的医疗单位接受红细胞输血的患者使用标准化的通用和贫血症状特异性HRQoL仪器。主要结局是输血后第1天和第7天HRQoL评分与输血当天（第0天）基线值的变化。采用多元线性回归分析研究输血策略及其他因素对PRO的影响。结果分析对象为99例普通医疗患者。输血前血红蛋白水平中位数（四分位数范围）为72 (66-78)g/L。45名患者（45%）在第0天接受了2个或更多单位的红细胞治疗。癌症治疗-贫血亚量表的功能评估在第1天和第7天显著改善，效应量分别为0.41和0.38 (p
BACKGROUNDPhysical variables like mortality or cardiac events were used to evaluate the requirement of red blood cell (RBC) transfusion. However, patient-reported outcomes (PROs) of blood transfusion recipients were seldom assessed. The health-related quality of life (HRQoL) of patients before and after RBC transfusion was compared in this study.STUDY DESIGN AND METHODSThe study period was February to June 2016. Standardized generic and anemia symptom-specific HRQoL instruments were administered to patients receiving RBC transfusion in the medical unit of a single center. The primary outcome was the change in HRQoL scores on Days 1 and 7 posttransfusion from baseline values on the day of transfusion (Day 0). Multiple linear regression analysis was performed to study the effect of transfusion strategy and other factors on PRO.RESULTSThe analysis included 99 general medical patients. The median (interquartile range) pretransfusion hemoglobin level was 72 (66-78) g/L. Two or more units of RBCs were prescribed to 45 patients (45%) on Day 0. Functional Assessment of Cancer Therapy-Anemia Subscale improved significantly on Days 1 and 7 by effect sizes of 0.41 and 0.38, respectively (p