Association between anxiety and descending pain modulation of thermal stimuli in patients with burning mouth syndrome: a cross-sectional study.

Association between anxiety and descending pain modulation of thermal stimuli in patients with burning mouth syndrome: a cross-sectional study.
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灼口综合征患者焦虑与热刺激下降疼痛调节之间的关联：一项横断面研究。

DOI：
10.11607/ofph.3050
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发表时间：
2022
期刊：
J Oral Facial Pain Headache
影响因子：
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通讯作者：
Ozasa K，Noma N，Kobayashim M，Takizawa K，Young A，Eliav E，Imamura Y
Ozasa K，Noma N，Kobayashim M，Takizawa K，Young A，Eliav E，Imamura Y
中科院分区：
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文献类型：
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作者：
T. Takahashi;Y. Nishimura;T. Gonda;K. Ikebe;Ozasa K，Noma N，Kobayashim M，Takizawa K，Young A，Eliav E，Imamura Y

文献摘要

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目的探讨抑郁和焦虑对条件性疼痛调制（CPM）的预测能力，并研究40°C下CPM和47°C下CPM与灼口综合征（BMS）患者年龄、疾病相关疼痛、疼痛持续时间和心理社会因素的关系。时间总和被用作CPM的测试刺激，随后暴露于无痛（40°C）或疼痛（47°C）Peltier热电极被用作条件刺激。CPM计算为条件刺激后疼痛感知的差异。心理社会因素进行了检查，使用情绪状态（POMS）和状态-特质焦虑量表（STAI）的配置文件。结果状态焦虑和紧张焦虑评分与BMS患者比对照组参与者显着较高。多元回归分析显示，CPM 47 °C受到活力、疲劳、混乱和特质焦虑的影响（调整后R2 = 0.685，F = 5.147，P = 0.098）。CPM 40 °C的相应分析表明，该模型对以下变量没有预测性：疾病相关疼痛、疼痛持续时间或POMS或STAI的组成部分。CPM 47 °C与特质焦虑呈显著正相关，提示特质焦虑对内源性疼痛调节系统有负性影响。这些发现表明CPM损伤和特质焦虑的增加参与了BMS的发展。J Oral Facial Pain Headache 2022;35：67-77. doi：10.11607/ofph.3050
AimsTo investigate the predictive power of depression and anxiety for conditioned pain modulation (CPM) and to examine the relationships of CPM at 40°C and CPM at 47°C with age, disease-related pain, pain duration, and psychosocial factors in burning mouth syndrome (BMS).MethodsA total of 22 patients with BMS and 22 healthy female controls participated in this study. Temporal summation was used as the test stimulus for CPM, and subsequent exposure either to a nonpainful (40°C) or a painful (47°C) Peltier thermode was used as the conditioning stimulus. CPM was calculated as the difference in pain perception following the conditioning stimulus. Psychosocial factors were examined using the Profile of Mood States (POMS) and the State-Trait Anxiety Inventory (STAI).ResultsState anxiety and tension-anxiety scores were significantly higher for patients with BMS than for control participants. Multiple regression analyses showed that CPM47°C was affected by vigor, fatigue, confusion, and trait anxiety (adjusted R2 = 0.685, F = 5.147, P = .098). The corresponding analysis for CPM40°C showed that the model was not predictive for the following variables: disease-related pain, pain duration, or components of the POMS or STAI. A significant positive correlation was found between CPM47°C and trait anxiety, suggesting that trait anxiety negatively affected the endogenous pain modulation system.ConclusionIncreases in trait anxiety reduced the CPM effect. These findings suggest that CPM impairments and increases in trait anxiety are involved in the development of BMS. J Oral Facial Pain Headache 2022;35:67–77. doi: 10.11607/ofph.3050