The Common and Distinct Orientation Adaptation Effect at Pinwheel Centers in Areas 21a and 17 of Cats.
The Common and Distinct Orientation Adaptation Effect at Pinwheel Centers in Areas 21a and 17 of Cats.
复制标题
猫 21a 和 17 区风车中心的共同和独特的方向适应效应。
DOI：
10.1016/j.neuroscience.2018.03.005
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发表时间：
2018
期刊：
影响因子：
3.3
通讯作者：
Yu Hongbo
中科院分区：
文献类型：
--
作者：
Meng Jianjun;Li Zhong;Li Hongjian;Zhu Jianbin;Yu Hongbo
皮质的适应性变化能力是不一致的。在猫区域 17 中，方向图的风车中心在方向适应后表现出比等方向域更大的选择性变化（Dragoi 等人，2001a）。然而，这种异质性是否存在于其他视觉皮层区域仍不清楚。与区域 17 类似，众所周知，猫的区域 21a 神经元根据其在等方向域中的方向偏好进行功能聚集，这些方向聚集在风车中心，但具有更高的风车密度（Huang 等，2006）。在本研究中，我们通过内在信号光学成像同时测量了麻醉猫区域 17 和区域 21a 方向图的适应效果。我们发现，在区域 21a 中，适应引起的选择性变化在风车中心处显着更大，与区域 17 中的发现类似。然而，无论是在风车中心还是等方向域，区域 21a 中的选择性变化始终大于区域 17 中的选择性变化，尽管两个区域中方向分布的异质性相似。更重要的是，在我们的短期适应协议中，区域 17 的方向适应导致了风车中心区域的大部分排斥性变化，而在区域 21a 中，它引起了排斥和吸引效应。这些结果表明，跨皮质和次区域的方向适应存在共同和独特的策略。
Cortices are non-uniform in their capacity for adaptive changes. In cat area 17, pinwheel centers of the orientation map demonstrated much greater selectivity shifts after the orientation adaptation than the iso-orientation domains (Dragoi et al., 2001a). However, whether this heterogeneity exists in other visual cortical regions remains unclear. Similar to area 17, area 21a neurons in cats are well known to be functionally clustered according to their orientation preference in iso-orientation domains that converge at pinwheel centers but with a higher pinwheel density (Huang et al., 2006). In this study, we simultaneously measured the adaptation effects on the orientation maps in area 17 and area 21a of anesthetized cats by intrinsic signal optical imaging. We found that in area 21a, the adaptation-induced selectivity shifts were significantly larger at pinwheel centers, similar to the findings in area 17. However, at either pinwheel centers or iso-orientation domains, the selectivity shifts in area 21a were all consistently greater than those in area 17, even though the heterogeneity in the orientation distribution was similar in the two areas. More importantly, in our short-term adaptation protocol, orientation adaptation in area 17 resulted in mostly repulsive shifts at the pinwheel center region, while in area 21a, it induced both repulsive and attractive effects. These results suggest that both common and distinct strategies exist for orientation adaptation across cortices and sub-regions.