Molecular networks underlying myofibroblast fate and fibrosis.
Molecular networks underlying myofibroblast fate and fibrosis.
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DOI：
10.1016/j.yjmcc.2016.05.002
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发表时间：
2016-08
影响因子：
5
通讯作者：
Davis J
中科院分区：
文献类型：
--
作者：
Stempien-Otero A;Kim DH;Davis J
纤维化重构是大多数形式的心血管疾病的标志，并且是向心力衰竭进展的强预后指标。肌成纤维细胞是一种专门用于细胞外基质（ECM）分泌和组织收缩的异质细胞类型，是心脏纤维化反应的主要效应子。本文综述了肌成纤维细胞的生理学、其祖细胞群以及协调肌成纤维细胞分化的核心信号网络，作为理解心脏和其他组织纤维化疾病基本决定因素的一种方式。
Fibrotic remodeling is a hallmark of most forms of cardiovascular disease and a strong prognostic indicator of the advancement towards heart failure. Myofibroblasts, which are a heterogeneous cell-type specialized for extracellular matrix (ECM) secretion and tissue contraction, are the primary effectors of the heart’s fibrotic response. This review is focused on defining myofibroblast physiology, its progenitor cell populations, and the core signaling network that orchestrates myofibroblast differentiation as a way of understanding the basic determinants of fibrotic disease in the heart and other tissues.