INFLUENCE OF THE SEVERITY AND DURATION OF MURINE ANTIGEN-INDUCED ARTHRITIS ON CARTILAGE PROTEOGLYCAN SYNTHESIS AND CHONDROCYTE DEATH
INFLUENCE OF THE SEVERITY AND DURATION OF MURINE ANTIGEN-INDUCED ARTHRITIS ON CARTILAGE PROTEOGLYCAN SYNTHESIS AND CHONDROCYTE DEATH
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DOI：
10.1002/art.1780280713
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发表时间：
1985-01-01
影响因子：
--
通讯作者：
VANDEPUTTE, LBA
中科院分区：
文献类型：
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作者：
KRUIJSEN, MWM;VANDENBERG, WB;VANDEPUTTE, LBA
最近的研究表明，关节炎症可以抑制软骨细胞蛋白多糖的合成，甚至可以杀死软骨细胞。研究了小鼠抗原诱导的关节炎的严重程度和慢性程度对软骨细胞毒性作用程度的影响。关节炎症，定量测量99 mTc高锝酸盐摄取，与蛋白多糖合成的抑制，测量35 S-硫酸掺入显着相关。关节炎诱导后第28天软骨细胞死亡程度的组织学分级与第14天存在的炎症程度最相关。软骨细胞死亡的高分数仅在患有持续性严重关节炎的小鼠中发现。关节炎症的严重程度是软骨细胞蛋白聚糖合成抑制程度的主要决定因素，而炎症的严重程度和慢性程度决定了软骨细胞的杀伤，因此决定了不可逆的关节破坏。
Recent studies have shown that joint inflammation can suppress chondrocyte proteoglycan synthesis and can even kill chondrocytes. The influence of the severity and chronicity of murine antigen-induced arthritis was investigated on the degree of these toxic effect on chondrocytes. Joint inflammation, quantitated by measurements of 99mTc pertechnetate uptake, was significantly correlated with the inhibition of proteoglycan synthesis, measured by 35S-sulfate incorporation. Histologic grading of the extent of chondrocyte death on day 28 after arthritis induction correlated best with the degree of inflammation present on day 14. High scores for chondrocyte death were found only in mice with persistent, severe arthritis. The severity of joint inflammation is a major determinant of the degree of chondrocyte proteoglycan synthesis inhibition, whereas both the severity and chronicity of the inflammation determine chondrocyte killing and, therefore, irreversible joint destruction.